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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/9754
Title: Toxicopathological studies on the effects of T-2 mycotoxin and their interaction in juvenile goats
Authors: Nayakwadi S.
Ramu R.
Sharma A.K.
Gupta V.K.
Rajukumar K.
Kumar V.
Shirahatti P.S.
Rashmi L.
Basalingappa K.M.
Published in: PLoS ONE
Abstract: Food and feeds contaminated with mycotoxins have been a threat to the rearing industry by causing some of the most fatal toxic reactions not only in the farm animals but also in humans who consume them. Toxicity to juvenile goats was induced by feed contamination with T-2 toxin (at 10 and 20 ppm dosage; group I and II, respectively). The toxicity impact was assessed on days 15 and 30 post treatment with respect to growth performance, oxidative stress, apoptotic studies and detailed pathomorphology. The study revealed that apart from the obvious clinical toxicosis (weakness, lethargy, and retardation in growth), the toxin fed groups also exhibited significant haematological (reduced hemoglobin, total leukocyte and thrombocyte counts) and biochemical changes (increased levels of oxidative stress markers with concomitant decrease in levels of serum and tissue catalase and superoxide dismutase). The pathomorphological and histological alterations suggested that the liver and intestine were the most affected organs. Ultra-structurally, varying degrees of degeneration, cytoplasmic vacuolations and pleomorphic mitochondria were observed in the hepatocytes and the enterocytes of the intestine. Kidney also revealed extensive degeneration of the cytoplasmic organelles with similar condensation of the heterochromatin whereas the neuronal degeneration was characterized by circular, whirling structures. In addition, the central vein and portal triad of the hepatocytes, cryptic epithelial cells of the intestine, MLNs in the lymphoid follicles, PCT and DCT of the nephronal tissues and the white pulp of the spleen exhibited extensive apoptosis. In this study, it was also observed that the expression of HSPs, pro-apoptotic proteins and pro-inflammatory cytokines were significantly upregulated in response to the toxin treatment. These results suggest that the pathogenesis of T-2 toxicosis in goats employs oxidative, apoptotic and inflammatory mechanisms. © 2020 Nayakwadi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation: PLoS ONE (2020), 15(3): -
URI: https://doi.org/10.1371/journal.pone.0229463
http://repository.iitr.ac.in/handle/123456789/9754
Issue Date: 2020
Publisher: Public Library of Science
ISSN: 19326203
Author Scopus IDs: 56033084100
56374665500
57203774408
56733968000
18837578000
57197697471
56374605800
57215968256
53979469900
Author Affiliations: Nayakwadi, S., Central Institute for Research on Goats (CIRG), Makhdoom, Mathura, India, Animal Science Section, ICAR-Central Coastal Agricultural Research Institute, Ela, Goa, India
Ramu, R., Division of Biotechnology and Bioinformatics, Department of Water & Health Sciences, Faculty of Life Sciences, JSS Academy of Higher Education and Research (Deemed to be University), Mysuru, India
Sharma, A.K., Central Institute for Research on Goats (CIRG), Makhdoom, Mathura, India, Division of Pathology, Mycotic and Mycotoxic Diseases Laboratory, Indian Veterinary Research Institute, Izatnagar, India
Gupta, V.K., CADRAD, ICAR–Indian Veterinary Research Institute, Izatnagar, India
Rajukumar, K., ICAR–National Institute of High Security Animal Diseases, Bhopal, India
Kumar, V., Central Institute for Research on Goats (CIRG), Makhdoom, Mathura, India
Shirahatti, P.S., Department of Biotechnology, Teresian College, Siddhartha Nagara, Mysuru, India
Rashmi, L., Karnataka Veterinary Animal Fisheries University, Bidar, Karnataka, India
Basalingappa, K.M., Division of Molecular Biology, Department of Water & Health Sciences, Faculty of Life Sciences, JSS Academy of Higher Education and Research (Deemed to be University), Mysuru, India
Corresponding Author: Nayakwadi, S.; Central Institute for Research on Goats (CIRG)India; email: drshivasharan@gmail.com
Appears in Collections:Journal Publications [MS]

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