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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/9713
Title: Studies on apoptotic changes in combined toxicity of citrinin and endosulfan in pregnant wistar rats and their fetuses
Authors: Singh N.D.
Sharma A.K.
Dwivedi P.
Telang A.G.
Kumar M.
Patil R.D.
Published in: Toxicology International
Abstract: Background: Citrinin (mycotoxin) and endosulfan (pesticide) both environmental contaminants easily enter the food chain and are caoomon causes of various toxicities. Materials and Methods: In the present investigation, citrinin (CIT) (10 mg/kg feed) and endosulfan (1 mg/kg body weight) were administered orally alone and in combination to pregnant Wistar rats from gestational day 6 to 20 to study their effect to cause apoptosis in the pregnant Wistar rats and their fetuses. Apoptosis was assessed in dams by agarose gel electrophoresis, flow cytometry and electron microscopy, while in the fetuses it was assessed by flow cytometry only. Result: Citrinin and endosulfan in the combination group caused apoptosis in an additive manner as there was increased number of apoptotic cells as compared to the individual toxin and control groups. The fetuses also showed increased number of apoptotic cells in the combination groups, which also indicated that both the toxins crossed the placental barrier. Conclusion: So it was concluded that apoptosis played a significant role in the pathogenesis of endosulfan and citrinin toxicity.
Citation: Toxicology International (2012), 19(2): 138-143
URI: https://doi.org/10.4103/0971-6580.97207
http://repository.iitr.ac.in/handle/123456789/9713
Issue Date: 2012
Keywords: Apoptosis
Citrinin
Endosulfan
Fetuses
Pregnant dams
ISSN: 9716580
Author Scopus IDs: 57193824761
57203774408
57210229309
6603887038
55617246300
26429964700
Author Affiliations: Singh, N.D., COVS, GADVASU, Ludhiana, India
Sharma, A.K., Division of Pathology, Indian Veterinary Research Institute, Izatnagar - 243 122, Bareilly, Uttar Pradesh, India
Dwivedi, P., Division of Pathology, Indian Veterinary Research Institute, Izatnagar - 243 122, Bareilly, Uttar Pradesh, India
Telang, A.G., CADRAD, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India
Kumar, M., HSADL, Bhopal, Madhya Pradesh, India
Patil, R.D., Department of Veterinary Pathology, GC Negi COVS, CSKHPKVV, Palampur, Himachal Pradesh, India
Corresponding Author: Sharma, A.K.; Division of Pathology, Indian Veterinary Research Institute, Izatnagar - 243 122, Bareilly, Uttar Pradesh, India; email: aksharmaivri@rediffmail.com
Appears in Collections:Journal Publications [MS]

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