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dc.contributor.authorSharma V.K.-
dc.contributor.authorKoka A.-
dc.contributor.authorYadav J.-
dc.contributor.authorSharma A.K.-
dc.contributor.authorKeservani R.K.-
dc.date.accessioned2020-10-09T11:53:26Z-
dc.date.available2020-10-09T11:53:26Z-
dc.date.issued2016-
dc.identifier.citationArs Pharmaceutica (2016), 57(3): 97-109-
dc.identifier.issn42927-
dc.identifier.urihttps://doi.org/10.4321/S2340-98942016000300001-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/9696-
dc.description.abstractAim: Oral route has always been the favorite route of drug administration in many diseases and till today it is the first way investigated in the development of new dosage forms. The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility, thereby pose problems in their formulation. For the therapeutic delivery of lipophilic active moieties (BCS class II drugs), lipid based formulations are inviting increasing attention. Methods: To that aim, from the web sites of PubMed, HCAplus, Thomson, and Registry were used as the main sources to perform the search for the most significant research articles published on the subject. The information was then carefully analyzed, highlighting the most important results in the formulation and development of self-micro emulsifying drug delivery systems as well as its therapeutic activity. Results: Self-emulsifying drug delivery system (SMEDDS) has gained more attention due to enhanced oral bio-availability enabling reduction in dose, more consistent temporal profiles of drug absorption, selective targeting of drug(s) toward specific absorption window in GIT, and protection of drug(s) from the unreceptive environment in gut. Conclusions: This article gives a complete overview of SMEDDS as a promising approach to effectively deal with the problem of poorly soluble molecules.-
dc.language.isoen_US-
dc.publisherEditorial Universida de Granada-
dc.relation.ispartofArs Pharmaceutica-
dc.subjectBioavailability-
dc.subjectCo-surfactant-
dc.subjectOil-
dc.subjectSMEDDS-
dc.subjectSurfactant-
dc.titleSelf-micro emulsifying drug delivery systems: A strategy to improve oral bioavailability-
dc.typeReview-
dc.scopusid57211762717-
dc.scopusid57193163627-
dc.scopusid57213104563-
dc.scopusid57203774408-
dc.scopusid36137230800-
dc.affiliationSharma, V.K., School of Pharmaceutical Sciences, Jaipur National University, Jaipur, 302025, India-
dc.affiliationKoka, A., Mallareddy Institute of Pharmaceutical Sciences, Secunderabad, Andhra Pradesh 500014, India-
dc.affiliationYadav, J., Delhi Institute of Pharmaceutical Sciences and Research, Formerly College of Pharmacy, University of Delhi, Pushp Vihar, Sector III, New Delhi, 110017, India-
dc.affiliationSharma, A.K., Delhi Institute of Pharmaceutical Sciences and Research, Formerly College of Pharmacy, University of Delhi, Pushp Vihar, Sector III, New Delhi, 110017, India-
dc.affiliationKeservani, R.K., School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, 462036, India-
dc.description.correspondingauthorKeservani, R.K.; School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki VishwavidyalayaIndia; email: rajksops@gmail.com-
Appears in Collections:Journal Publications [MS]

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