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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/9696
Title: Self-micro emulsifying drug delivery systems: A strategy to improve oral bioavailability
Authors: Sharma V.K.
Koka A.
Yadav J.
Sharma A.K.
Keservani R.K.
Published in: Ars Pharmaceutica
Abstract: Aim: Oral route has always been the favorite route of drug administration in many diseases and till today it is the first way investigated in the development of new dosage forms. The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility, thereby pose problems in their formulation. For the therapeutic delivery of lipophilic active moieties (BCS class II drugs), lipid based formulations are inviting increasing attention. Methods: To that aim, from the web sites of PubMed, HCAplus, Thomson, and Registry were used as the main sources to perform the search for the most significant research articles published on the subject. The information was then carefully analyzed, highlighting the most important results in the formulation and development of self-micro emulsifying drug delivery systems as well as its therapeutic activity. Results: Self-emulsifying drug delivery system (SMEDDS) has gained more attention due to enhanced oral bio-availability enabling reduction in dose, more consistent temporal profiles of drug absorption, selective targeting of drug(s) toward specific absorption window in GIT, and protection of drug(s) from the unreceptive environment in gut. Conclusions: This article gives a complete overview of SMEDDS as a promising approach to effectively deal with the problem of poorly soluble molecules.
Citation: Ars Pharmaceutica (2016), 57(3): 97-109
URI: https://doi.org/10.4321/S2340-98942016000300001
http://repository.iitr.ac.in/handle/123456789/9696
Issue Date: 2016
Publisher: Editorial Universida de Granada
Keywords: Bioavailability
Co-surfactant
Oil
SMEDDS
Surfactant
ISSN: 42927
Author Scopus IDs: 57211762717
57193163627
57213104563
57203774408
36137230800
Author Affiliations: Sharma, V.K., School of Pharmaceutical Sciences, Jaipur National University, Jaipur, 302025, India
Koka, A., Mallareddy Institute of Pharmaceutical Sciences, Secunderabad, Andhra Pradesh 500014, India
Yadav, J., Delhi Institute of Pharmaceutical Sciences and Research, Formerly College of Pharmacy, University of Delhi, Pushp Vihar, Sector III, New Delhi, 110017, India
Sharma, A.K., Delhi Institute of Pharmaceutical Sciences and Research, Formerly College of Pharmacy, University of Delhi, Pushp Vihar, Sector III, New Delhi, 110017, India
Keservani, R.K., School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, 462036, India
Corresponding Author: Keservani, R.K.; School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki VishwavidyalayaIndia; email: rajksops@gmail.com
Appears in Collections:Journal Publications [MS]

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