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Title: Effect of feeding graded doses of Citrinin on clinical and teratology in female Wistar rats
Authors: Singh N.D.
Sharma A.K.
Patil R.D.
Rahman S.
Leishangthem G.D.
Kumar M.
Published in: Indian Journal of Experimental Biology
Abstract: Citrinin is the one of the well-known mycotoxins, which is possibly spread all over the world. The graded doses of citrinin (1, 3 and 5 ppm CIT in feed) in female Wistar rats 10 weeks prior to mating, during mating and during organogenesis resulted in resorptions and post implantation losses, decreased fetal body weights and crown-rump lengths in fetuses of all groups. Various developmental anomalies recorded in fetuses of treated rats included gross (wrist drop, curled tail, stretched forelimb, subcutaneous haematoma), skeletal (incomplete ossification of skull bones, incomplete fusion of vertebral bodies, complete and partial agenesis of sternaebrae, metacarpals, metatarsals and phalanges, fused ribs and swing out ribs) and visceral (internal and external hydrocephalus, cerebellar hypoplasia, microphthalmia, roundening of heart, contracted kidneys, dilated renal pelvis and cryptorchid testes). The results suggest that CIT has adverse effects on fetal development which may be due to the longer bioavailability of citrinin in the animals.
Citation: Indian Journal of Experimental Biology (2014), 52(2): 159-167
Issue Date: 2014
Keywords: Anomalies
ISSN: 195189
Author Scopus IDs: 57193824761
Author Affiliations: Singh, N.D., Division of Pathology Indian Veterinary Research Institute, Izatnagar 243 122, India
Sharma, A.K., Division of Pathology Indian Veterinary Research Institute, Izatnagar 243 122, India
Patil, R.D., Department of Veterinary Pathology, College of Veterinary Science, CSKHPKVV, Palampur 176 062, India
Rahman, S., Department of Veterinary Pathology, College of Veterinary Science, SKUAST, Jammu 181 102, India
Leishangthem, G.D., Department of Pathology, All India Institute of Medical Sciences, New Delhi 110 029, India
Kumar, M., High Security Animal Disease Laboratory, Bhopal 462 021, India
Corresponding Author: Singh, N. D.; College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana 144 002, India; email:
Appears in Collections:Journal Publications [MS]

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