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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/9392
Title: Cancer chemoprevention by flavonoids, dietary polyphenols and terpenoids
Authors: Sheikh I.
Sharma V.
Tuli H.S.
Aggarwal D.
Sankhyan A.
Vyas P.
Sharma A.K.
Bishayee A.
Published in: Biointerface Research in Applied Chemistry
Abstract: The world population is aging, and cancer is always considered to be one of the major causes of death all over the globe. The advent of recent drug-targeted therapies undoubtedly is going to reduce the incidence of cancer over the coming years. However, the frequency of occurrence of such chronic diseases like cancer would continue to increase. Therefore, the search for a safer and cost-effective treatment is urgently needed. Phytochemicals found in plants, foods, vegetables, tea, etc. have emerged as proven therapeutic compounds modulating signaling pathways involved in cancer. We carried out a structured search of bibliographic databases for peer-reviewed research literature using the keywords: cancer chemoprevention, flavonoids, dietary polyphenols, terpenoids, bioactive, microbiota. Quality of the retrieved papers and characteristic outcomes of the articles included in the study was assessed by employing standard tools and deductive qualitative content analysis methodology. The development of personalized supplements comprising particular phytochemicals has been the key, especially dealing with chronic inflammatory disorders like cancer. Better understanding at the molecular level explains the influence of phytochemicals on human health, which has been extensively covered through this review. Moreover, the wide collection of dietary polyphenols that has significant properties in reference to human health has been highlighted. Furthermore, the etiology of end products of such phytochemicals, especially on the modulation of gut microbiota and the host-microbial interactions thereof, need to be properly understood. The present study summarizes the chemoprevention and treatment of cancer using the bioactive components, including flavonoids, dietary polyphenols, and terpenoids. Likewise, the effect of dietary polyphenols on the human gut microbiota has been realized more recently. However, more research is needed in this field, especially focused on the communications, interlinks between the gut microbiota and polyphenols with the precise mechanism of action. © 2020 by the authors.
Citation: Biointerface Research in Applied Chemistry (2020), 11(1): 8502-8537
URI: https://doi.org/10.33263/BRIAC111.85028537
http://repository.iitr.ac.in/handle/123456789/9392
Issue Date: 2020
Publisher: AMG Transcend Association
Keywords: Bioactive
Cancer chemoprevention
Dietary Polyphenols
Flavonoids
Microbiota
Terpenoids
ISSN: 20695837
Author Scopus IDs: 56596417500
57218564079
55599516400
36155245700
57218562715
55833557500
57203774408
7003849269
Author Affiliations: Sheikh, I., Department of Biotechnology, Eternal University, Baru Sahib, SirmourHimachal Pradesh, India
Sharma, V., Department of Biotechnology, Sri Guru Gobind Singh College, Sector-26, Chandigarh, UT 160019, India
Tuli, H.S., Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India
Aggarwal, D., Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India
Sankhyan, A., Department of Dentistry, Swami Devi Dyal Hospital, and Dental College, Panchkula, Haryana, India
Vyas, P., Department of Biotechnology, Eternal University, Baru Sahib, SirmourHimachal Pradesh, India
Sharma, A.K., Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India
Bishayee, A., Lake Erie College of Osteopathic Medicine, 5000 Lakewood Ranch Boulevard, Bradenton, FL 34211, United States
Funding Details: We sincerely apologize to those whose work could not be cited owing to space limitations. The authors are grateful to the M.M. (Deemed to be University) for providing the requisite platform to write this article.
Corresponding Author: Sharma, A.K.; Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, India; email: anibiotech18@gmail.com
Appears in Collections:Journal Publications [MS]

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