Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/9334
Title: Ameliorative effect of ursolic acid on renal fibrosis in adenine-induced chronic kidney disease in rats
Authors: Thakur R.
Sharma A.
Lingaraju M.C.
Begum J.
Kumar D.
Mathesh K.
Kumar P.
Singh T.U.
Kumar D.
Published in: Biomedicine and Pharmacotherapy
Abstract: Ursolic acid (UA), an ursane-type pentacyclic triterpenoid commonly found in apple peels and holy basil has been shown to possess many beneficial effects. Renal fibrosis is a complication of kidney injury and associated with increased risk of morbidity and mortality. In our previous investigation, a lupane-type pentacyclic triterpenoid, betulinic acid (BA) was found to have protective effect on chronic kidney disease (CKD) and renal fibrosis. This prompted us to explore the therapeutic value of UA, a chemically related compound to BA in CKD. CKD was induced by feeding adenine with the feed at a concentration of 0.75% for 28 days. UA at the dose rate of 30 mg/kg in 0.5% carboxy methyl cellulose (CMC) was administered by oral route, simultaneously with adenine feeding for 28 days. Adenine feeding increased the kidney weight to body weight index, decreased the kidney function due to injury as indicated by increased markers like serum urea, uric acid, creatinine, cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) and initiated the fibrotic response in kidney by increasing the profibrotic proteins viz. transforming growth factor-beta (TGF-β), connective tissue growth factor (CTGF), fibronectin and collagen. However, treatment with UA reversed the damage induced by adenine as shown by reduced kidney injury and fibrosis markers which was further clearly evident in histological picture indicating the suitability of UA for use in CKD. © 2018 Elsevier Masson SAS
Citation: Biomedicine and Pharmacotherapy (2018), 101(): 972-980
URI: https://doi.org/10.1016/j.biopha.2018.02.143
http://repository.iitr.ac.in/handle/123456789/9334
Issue Date: 2018
Publisher: Elsevier Masson SAS
Keywords: Chronic kidney disease
Rats
Renal fibrosis
Transforming growth factor
Ursolic acid
ISSN: 7533322
Author Scopus IDs: 57201541775
57203774408
55581017800
56127029500
57211016614
56048117300
57075407600
25643590700
57211196210
Author Affiliations: Thakur, R., Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, UP 243 122, India
Sharma, A., Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, UP 243 122, India
Lingaraju, M.C., Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, UP 243 122, India
Begum, J., Department of Veterinary Microbiology, College of Veterinary & Animal Sciences, G. B. Pant University of Agriculture and Technology, Pantnagar, 263153, United Kingdom
Kumar, D., Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, UP 243 122, India
Mathesh, K., Centre for Wildlife Conservation Management and Disease Surveillance, Indian Veterinary Research Institute, Izatnagar, UP 243 122, India
Kumar, P., Division of Pathology, Indian Veterinary Research Institute, Izatnagar, UP 243 122, India
Singh, T.U., Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, UP 243 122, India
Kumar, D., Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, UP 243 122, India
Funding Details: The authors thank the Director and Joint Director (Academic), Indian Veterinary Research Institute, Izatnagar, India for providing financial support to conduct this study.
Corresponding Author: Lingaraju, M.C.; Division of Pharmacology & Toxicology, Indian Veterinary Research Institute, Izatnagar, India; email: maddyvet@gmail.com
Appears in Collections:Journal Publications [MS]

Files in This Item:
There are no files associated with this item.
Show full item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.