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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/8621
Title: Solid state investigation and characterization of the polymorphic and pseudopolymorphic forms of indapamide
Authors: Ghugare P.
Dongre V.
Karmuse P.
Rana R.
Singh D.
Kumar A.
Filmwala Z.
Published in: Journal of Pharmaceutical and Biomedical Analysis
Abstract: Solid state investigation and polymorphic screening of indapamide, a diuretic drug generally used for the treatment of hypertension was carried out. Substantial differences were obtained in the solid state properties of crystals confirming the existence of a polymorphic and three pseudopolymorphic forms of indapamide. Detailed methods of preparation of the polymorphs and pseudopolymorphs are described. X-ray powder diffraction (XRPD), diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were employed for the characterization of different crystalline forms of indapamide. The stoichiometric ratio of solvents associated with the drug molecules in the pseudopolymorphic forms were calculated using TGA, nuclear magnetic resonance (NMR) spectroscopy and headspace gas chromatographic (HS-GC) analysis. © 2009 Elsevier B.V. All rights reserved.
Citation: Journal of Pharmaceutical and Biomedical Analysis (2010), 51(3): 532-540
URI: https://doi.org/10.1016/j.jpba.2009.09.003
http://repository.iitr.ac.in/handle/123456789/8621
Issue Date: 2010
Keywords: Indapamide
Polymorphs
Pseudopolymorphs
Solid state characterization
XRPD
ISSN: 7317085
Author Scopus IDs: 15128526100
8537861700
8537861300
56225304000
57198856967
26663981200
15750632100
Author Affiliations: Ghugare, P., Nadkarni Sacasa Research Laboratory, Department of Chemistry, St. Xavier's College, Mumbai, 400001, India, Ipca Laboratories Ltd., Chemical Research Division, Kandivli Industrial Estate, Kandivli (W), Mumbai, 400 067, India, Department of Chemistry, University of Mumbai, Vidyanagari, Kalina, Santacruz (E), Mumbai 400 098, India
Dongre, V., Department of Chemistry, University of Mumbai, Vidyanagari, Kalina, Santacruz (E), Mumbai 400 098, India
Karmuse, P., Ipca Laboratories Ltd., Chemical Research Division, Kandivli Industrial Estate, Kandivli (W), Mumbai, 400 067, India, Department of Chemistry, University of Mumbai, Vidyanagari, Kalina, Santacruz (E), Mumbai 400 098, India
Rana, R., Ipca Laboratories Ltd., Chemical Research Division, Kandivli Industrial Estate, Kandivli (W), Mumbai, 400 067, India
Singh, D., Ipca Laboratories Ltd., Chemical Research Division, Kandivli Industrial Estate, Kandivli (W), Mumbai, 400 067, India
Kumar, A., Ipca Laboratories Ltd., Chemical Research Division, Kandivli Industrial Estate, Kandivli (W), Mumbai, 400 067, India
Filmwala, Z., Nadkarni Sacasa Research Laboratory, Department of Chemistry, St. Xavier's College, Mumbai, 400001, India
Corresponding Author: Ghugare, P.; Nadkarni Sacasa Research Laboratory, Department of Chemistry, St. Xavier's College, Mumbai, 400001, India; email: p_d_ghugare@yahoo.com
Appears in Collections:Journal Publications [ECE]

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