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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/8618
Title: Sitagliptin, sitagliptin and metformin, or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats
Authors: Sharma A.K.
Sharma A.
Kumari R.
Kishore K.
Sharma D.
Srinivasan B.P.
Sharma A.
Singh S.K.
Gaur S.
Jatav V.S.
Sharma P.
Srivastava V.
Joshi S.
Joshi M.
Dhakad P.K.
Kanawat D.S.
Mishra A.
Sharma A.
Singh D.
Singh R.P.
Chawda H.S.
Singh R.
Raikwar S.K.
Kurmi M.K.
Khatri P.
Agarwal A.
Munajjam A.
Published in: Journal of Biomedical Research
Abstract: Diabetic neuropathies are a family of nerve disorders caused by diabetes. Symptoms of the disease include nerve palsy, mononeuropathy, mononeuropathy multiplex, diabetic amyotrophy, painful polyneuropathy, autonomic neu-ropathy, and thoracoabdominal neuropathy. In this study, type 2 diabetes in rats was induced with nicotinamide-streptozotocin. Drug treatment was initiated on the d 15, with the combination regimen of metformin, pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin, amitriptyline and sitagliptin and led to significantly im-proved glycemic control, increased grip strength and paw jumping response on d 21, 28 and 35 (. P < 0.001). Signif-icant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21, 28 and 35 (. P < 0.001). Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells, while administration of metformin and sitagliptin showed tissue regen-eration and no body weight gain. In conclusion, treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain, but causes an increase in grip strength and pain sensitivity, exhibits neural protection, and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. © 2012 The Editorial Board of Journal of Biomedical Research.
Citation: Journal of Biomedical Research (2012), 26(3): 200-210
URI: https://doi.org/10.7555/JBR.26.20110054
http://repository.iitr.ac.in/handle/123456789/8618
Issue Date: 2012
Keywords: Amitriptyline
Diabetic neuropathy
Glimipiride
Metformin
Nicotinamide-streptozotocin
Pioglitazone
Sitagliptin
ISSN: 16748301
Author Scopus IDs: 57201794342
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Author Affiliations: Sharma, A.K., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Sharma, A., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Kumari, R., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Kishore, K., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Sharma, D., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Srinivasan, B.P., Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, Pushpvihar, New Delhi 110017, India
Sharma, A., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Singh, S.K., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Gaur, S., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Jatav, V.S., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Sharma, P., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Srivastava, V., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Joshi, S., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Joshi, M., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Dhakad, P.K., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Kanawat, D.S., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Mishra, A., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Sharma, A., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Singh, D., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Singh, R.P., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Chawda, H.S., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Singh, R., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Raikwar, S.K., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Kurmi, M.K., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Khatri, P., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India
Agarwal, A., Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, Pushpvihar, New Delhi 110017, India
Munajjam, A., Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India, Department of Pharmacology, Kota Collage of Pharmacy, RIICO Industrial Area, Ranpur, Kota (Rajasthan), Pincode, 302025, India
Corresponding Author: Sharma, A.K.; Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur (Rajasthan) 302025, India; email: ashishksharma2003@yahoo.com
Appears in Collections:Journal Publications [ECE]

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