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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/4169
Title: Solid, solution, and antitumor activity studies of mixed-ligand complexes with adenine-5-bromouracil base pair
Authors: Singh R.
Tyagi S.
Singh S.
Singh S.M.
Singh U.P.
Published in: Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry
Abstract: Mixed-ligand complexes of Co(II), Ni(Il), Cu(II), Zn(II) and Cd(II) with adenine as primary ligand and 5-bromouracil as secondary ligand were prepared in aqueous ethanol solution at pH of about 7 and subjected to a screening system of Dalton's Lymphoma (DL) tumor cells in vitro for the evaluation of viability, 3 H-thymidine incorporation and induction of apoptosis in tumor cells. The isolated complexes were characterized by various physico-chemical methods. Solution studies were performed pH-metrically for the interaction of the above metal ions with adenine and 5-bromouracil separately (binary) and in the presence of each other (ternary) at 25 ± 0.1°C temperature and a constant ionic strength of 0.1 M NaNO 3 in aqueous solution.
Citation: Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry (2002), 32(5): 853-872
URI: https://doi.org/10.1081/SIM-120005607
http://repository.iitr.ac.in/handle/123456789/4169
Issue Date: 2002
ISSN: 945714
Author Scopus IDs: 57198437313
7202432794
57206711794
7406398328
57203181883
Author Affiliations: Singh, R., Department of Chemistry, Indian Institute of Technology(formerly University of Roorkee), Roorkee, 247 667, India
Tyagi, S., Department of Chemistry, Indian Institute of Technology(formerly University of Roorkee), Roorkee, 247 667, India
Singh, S., Department of Chemistry and, Banaras Hindu University, Varanasi, 221 005, India
Singh, S.M., Department of Chemistry, Indian Institute of Technology(formerly University of Roorkee), Roorkee, 247 667, India
Singh, U.P., Department of Chemistry, Indian Institute of Technology(formerly University of Roorkee), Roorkee, 247 667, India
Funding Details: We are thankful to University Grant Commission, New Delhi for financial assistance.
Corresponding Author: Singh, U.P.; Department of Chemistry, Indian Institute of Technology, Roorkee 247 667, India; email: udaipfcy@rurkiu.ernet.in
Appears in Collections:Journal Publications [CY]

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