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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/4164
Title: Synthesis and reactivity studies of mononuclear zinc hydroxo complex
Authors: Tyagi S.
Sharma C.L.
Singh S.M.
Singh U.P.
Published in: Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry
Abstract: The synthesis of mononuclear zinc hydroxo, Zn(OH)(HB(3-Bu′-5- Pr′pz)3) 2 using sterically hindered pyrazolylborate ligand i.e. hydrotris(3-tert-butyl-5-isopropyl-1-pyrazolyl)borate ligand has been described. The structure of 2 is very similar to the active site of the enzyme carbonic anhydrase. The complex 2 is found to stabilize zinc complexes of uracil and its halo derivatives where uracil and its halo derivatives are bound as monodentate ligand via its deprotonated N1. The halogenated uracil complexes have been injected in Dalton's Lymphoma tumour system in mice and it is found that Zn[HB(3-Bu′-5-Pr′pz)3](5-fluorouracilate) exhibits significant antitumour activity. The complex 2 is a very reactive species and is used as catalyst in ester hydrolysis. The complex 2 is also found to promote the hydrolysis of various esters and the maximum rate of hydrolysis is observed with p-nitro-phenylacetate.
Citation: Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry (2004), 43(1): 83-87
URI: http://repository.iitr.ac.in/handle/123456789/4164
Issue Date: 2004
ISSN: 3764710
Author Scopus IDs: 7202432865
7202115093
7406398328
57203181883
Author Affiliations: Tyagi, S., Department of Chemistry, Indian Inst. of Technology Roorkee, Roorkee 247 667, India
Sharma, C.L., Department of Chemistry, Indian Inst. of Technology Roorkee, Roorkee 247 667, India
Singh, S.M., School of Biotechnology, Banaras Hindu University, Varanasi 221 005, India
Singh, U.P., Department of Chemistry, Indian Inst. of Technology Roorkee, Roorkee 247 667, India
Corresponding Author: Singh, U.P.; Department of Chemistry, Indian Inst. of Technology Roorkee, Roorkee 247 667, India
Appears in Collections:Journal Publications [CY]

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