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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/4070
Title: A Rapid One-Pot Five Component Sequential Access to Novel Imidazo[2,1-b]thiazinyl-α-aminophosphonates
Authors: Kaur T.
Saha D.
Singh N.
Singh U.P.
Sharma A.
Published in: ChemistrySelect
Abstract: A facile and rapid entry towards assembly of novel imidazo[2,1-b][1,3]thiazinyl-α-aminophosphonate scaffolds through a one-pot, sequential reaction of 2-amino-4H-1,3-thiazine-3-one, dialdehydes, isocyanides, aromatic amines and dialkyl/aryl phosphites is demonstrated. Successive sequencing of Groebke-Blackburn-Bienaymé (GBB) reaction with Kabachnik Field's reaction results in the efficient formation of novel bis-heterocyclic frameworks. The highlights of the present protocol include survival of the aldehydic group post GBB without any protection. Additionally, simplicity of execution excluding both solvent and catalyst, cheap reagents, excellent functional group tolerance under minutes of microwave irradiation justify it to be a green protocol. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Citation: ChemistrySelect (2016), 1(3): 434-439
URI: https://doi.org/10.1002/slct.201600070
http://repository.iitr.ac.in/handle/123456789/4070
Issue Date: 2016
Publisher: Wiley-Blackwell
Keywords: GBB reaction
Kabachnik Field's reaction.
Multicomponent reactions (MCRs)
[4+1] cycloaddition
ISSN: 23656549
Author Scopus IDs: 53986370200
56254856500
57211016562
57203181883
55605770309
Author Affiliations: Kaur, T., D-305, Medicinal Chemistry Lab, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Saha, D., D-305, Medicinal Chemistry Lab, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Singh, N., A-301, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Singh, U.P., A-301, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Sharma, A., D-305, Medicinal Chemistry Lab, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Funding Details: This work was financially supported by Science and Engineering Research Board (SERB), Govt. of India (Grant no. SER-892-CMD). Both the authors D.S. and T.K. gratefully acknowledge MHRD for the award of SRF and postdoctoral fellowship, respectively. One of the authors N.S. is thankful to UGC for research fellowship. The authors thank Dr. S. Saini (Southern Research Institute, Alabama, USA) for useful discussions.
Corresponding Author: Sharma, A.; D-305, Medicinal Chemistry Lab, Department of Chemistry, Indian Institute of Technology RoorkeeIndia; email: anujs77@gmail.com
Appears in Collections:Journal Publications [CY]

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