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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/3958
Title: Asymmetric Michael addition catalysed by sugar-based prolinamides in solvent-free conditions
Authors: Agarwal J.
Peddinti, Rama Krishna
Published in: Tetrahedron Letters
Abstract: Sugar-based prolinamides derived from glucosamine have been developed as organocatalysts for the asymmetric Michael addition between cyclohexanones and nitroolefins. Numerous polar and nonpolar solvents and additives have been screened in the current study. The organocatalyst 1c in the presence of benzoic acid as additive catalysed the reaction under neat conditions to afford Michael adducts in high yields (up to 98%) with excellent diastereoselectivities (up to >99:1) and moderate enantiomeric ratios (up to 84:16). © 2010 Elsevier Ltd. All rights reserved.
Citation: Tetrahedron Letters (2011), 52(1): 117-121
URI: https://doi.org/10.1016/j.tetlet.2010.10.148
http://repository.iitr.ac.in/handle/123456789/3958
Issue Date: 2011
ISSN: 404039
Author Scopus IDs: 56344053500
6602375630
Author Affiliations: Agarwal, J., Department of Chemistry, Indian Institute of Technology, Roorkee 247 667, Uttarakhand, India
Peddinti, R.K., Department of Chemistry, Indian Institute of Technology, Roorkee 247 667, Uttarakhand, India
Funding Details: We are grateful to DST, New Delhi , for the financial support (research Grant No. SR/S1/OC-15/2005 ). J.A. thanks UGC for the award of research fellowship.
Corresponding Author: Peddinti, R. K.; Department of Chemistry, Indian Institute of Technology, Roorkee 247 667, Uttarakhand, India; email: rkpedfcy@iitr.ernet.in
Appears in Collections:Journal Publications [CY]

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