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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/3935
Title: Hypervalent iodine mediated synthesis of di- and tri-substituted isoxazoles via [3+2] cycloaddition of nitrile oxides
Authors: Singhal A.
Parumala S.K.R.
Sharma A.
Peddinti, Rama Krishna
Published in: Tetrahedron Letters
Abstract: An efficient and rapid protocol for the synthesis of 3,4-disubstituted and 3,4,5-trisubstituted isoxazoles under catalyst-free conditions is described. This protocol involves pre-oxidation of aldoxime into nitrile oxide using diacetoxyiodobenzene. The in situ generated nitrile oxide was trapped with dipolarophiles for the formation of functionally rich isoxazoles via [3+2] cycloaddition. © 2015 Elsevier Ltd. All rights reserved.
Citation: Tetrahedron Letters (2016), 57(7): 719-722
URI: https://doi.org/10.1016/j.tetlet.2015.10.038
http://repository.iitr.ac.in/handle/123456789/3935
Issue Date: 2016
Publisher: Elsevier Ltd
Keywords: Acetylene carboxylates
Aldoximes
Diacetoxyiodobenzene
Isoxazoles
Nitrile oxides
ISSN: 404039
Author Scopus IDs: 57055032600
56257434200
55605770221
6602375630
Author Affiliations: Singhal, A., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India
Parumala, S.K.R., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India
Sharma, A., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India
Peddinti, R.K., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India
Funding Details: This work was supported by SERB – India (research grant No. SR/S1/OC-38/2011 ) and DST-FIST program (HRMS facility), New Delhi, and A.S. thanks MHRD and S.K.R.P. and A.S. thank CSIR for research fellowships.
Corresponding Author: Peddinti, R.K.; Department of Chemistry, Indian Institute of Technology RoorkeeIndia; email: rkpedfcy@iitr.ac.in
Appears in Collections:Journal Publications [CY]

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