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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/3927
Title: Harnessing the catalytic behaviour of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP): An expeditious synthesis of thioesters
Authors: Singh P.
Peddinti, Rama Krishna
Published in: Tetrahedron Letters
Abstract: A novel, efficient, metal-, base- and acid-free straightforward protocol has been developed for the construction of useful thioesters. The immense catalytic potential of HFIP for promoting the thiocarbonylation of acyl halides and thiols is disclosed. HFIP was recovered with ease and reused for further reactions without any loss of reactivity. Both aryl and alkyl thiols bearing electron-donating and electron-withdrawing groups as well as aryl- and alkyl acyl halides worked well in this reaction. Inexpensive precursors, short reaction time, obviating workup, high atom economy, and gram-scale preparation are the significant features of the developed eco-friendly route for S-carbonylation of thiols. © 2017 Elsevier Ltd
Citation: Tetrahedron Letters (2017), 58(19): 1875-1878
URI: https://doi.org/10.1016/j.tetlet.2017.04.004
http://repository.iitr.ac.in/handle/123456789/3927
Issue Date: 2017
Publisher: Elsevier Ltd
Keywords: Acid-free
Base-free
HFIP catalysis
High atom economy
Metal-free
ISSN: 404039
Author Scopus IDs: 56707905900
6602375630
Author Affiliations: Singh, P., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Peddinti, R.K., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Corresponding Author: Peddinti, R.K.email: rkpedfcy@iitr.ac.in
Appears in Collections:Journal Publications [CY]

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