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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/3670
Title: Characteristic spectral studies, and antimicrobial and anti-inflammatory activities of diorganotin(IV) derivatives of dipeptides
Authors: Nath, Mala
Yadav R.
Eng G.
Nguyen T.-T.
Kumar A.
Published in: Journal of Organometallic Chemistry
Abstract: New diorganotin(IV) complexes of general formula R2SnL (R = n-Bu and Ph, and L = dianion of alanylphenylalanine (H2L-1), phenylalanylleucine (H2L-2), phenylalanylphenylalanine (H2L-3), glycylleucine (H2L-4) and glycylisoleucine (H2L-5) have been prepared and characterised by elemental analyses, molar conductance, and the bonding in these complexes is discussed in terms of their IR, far-IR, 1H-, 13C- and 117Sn-NMR, and 119Sn Mössbauer spectral studies. The monomeric 1:1 complexes have distorted trigonal bipyramidal structure with cis-equatorial organic groups. The complexes, soluble in DMSO, have been screened against a wide spectrum of bacteria (Escherichia coli, Rhizobium meliloti, Pseudomonas putida and Aeromonas formicans) and fungi (Aspergillus niger, Pencillium chrysogenum, Aureobasidium pullulans and Verticillium dahliae) and are found to be active. The LD50 values (> 500 mg kg-1) have also been determined in the albino rats. Some of the complexes also exhibit very high anti-inflammatory activity. © 1999 Elsevier Science S.A. All rights reserved.
Citation: Journal of Organometallic Chemistry(1999), 577(1): 1-8
URI: https://doi.org/10.1016/S0022-328X(98)01017-1
http://repository.iitr.ac.in/handle/123456789/3670
Issue Date: 1999
Publisher: Elsevier
Keywords: Anti-inflammatory activity
Antimicrobial activity
Dipeptides
Organotin(IV)
ISSN: 0022328X
Author Scopus IDs: 7103033909
57189030008
7005770934
57209166787
36080047200
Author Affiliations: Nath, M., Department of Chemistry, University of Roorkee, Roorkee 247 667, India
Yadav, R., Department of Chemistry, University of Roorkee, Roorkee 247 667, India
Eng, G., Department of Chemistry, Univ. of the District of Columbia, Washington, DC 20008, United States
Nguyen, T.-T., Department of Chemistry, Univ. of the District of Columbia, Washington, DC 20008, United States
Kumar, A., Department of Pharmacology, LLRM Medical College, Meerut 250 004, India
Funding Details: This work was a part of a research project sponsored by UGC, New Delhi, India. The authors thank to the UGC for financial support. R. Yadav is thankful to CSIR, New Delhi for the award of a Senior Research Fellowship.
Corresponding Author: Nath, M.; Department of Chemistry, University of Roorkee, Roorkee 247 667, India; email: chem@rurkiv.ernet.in
Appears in Collections:Journal Publications [CY]

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