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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/3669
Title: Characteristic spectral studies and in vitro antimicrobial and in vivo multi-infection antifungal activities in mice of new organotin(IV) derivatives of heterocyclic amino acids
Authors: Nath, Mala
Yadav R.
Eng G.
Musingarimi P.
Published in: Applied Organometallic Chemistry
Abstract: The nature of the products obtained on reacting R3SnCl (R = Me, Bu and Ph), Ph2SnCl2 and Bu2SnO with amino acids having nitrogen-containing heterocyclic rings; i.e. L-histidine and DL-tryptophan, is shown to depend upon the reaction conditions. Ten new organotin(IV) derivatives of these amino acids have been synthesized and characterized by elemental analyses, molar conductance and electronic spectra, and the bonding in these complexes is discussed in terms of their infrared, far-infrared, 1H and 13C NMR, and 119Sn Mössbauer spectra. The complexes soluble in DMSO have been tested in vitro against a wide spectrum of bacteria and fungi and found to be active. Two complexes, Ph3SnL-1 and Ph3SnL-2, have been found to be slightly active in vivo against a multi-infection fungal model in mice. Copyright © 1999 John Wiley & Sons, Ltd.
Citation: Applied Organometallic Chemistry(1999), 13(1): 29-37
URI: http://repository.iitr.ac.in/handle/123456789/3669
Issue Date: 1999
Keywords: Amino acids
Antifungal activity
Antimicrobial activity
Multi-infection
Organotin
ISSN: 2682605
Author Scopus IDs: 7103033909
57189030008
7005770934
6507114457
Author Affiliations: Nath, M., Department of Chemistry, University of Roorkee, Roorkee 247 667, India
Yadav, R., Department of Chemistry, University of Roorkee, Roorkee 247 667, India
Eng, G., Department of Chemistry, Univ. of the District of Columbia, Washington, DC 20008, United States
Musingarimi, P., Department of Chemistry, Univ. of the District of Columbia, Washington, DC 20008, United States
Corresponding Author: Nath, M.; Department of Chemistry, University of Roorkee, Roorkee 247 667, India
Appears in Collections:Journal Publications [CY]

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