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Title: Design and microwave-assisted synthesis of tri- and dialkyltin(IV) hippurates, characterization, in vitro anti-cancer and in vivo anti-inflammatory activities
Authors: Nath, Mala
Vats M.
Roy, Partha
Published in: Medicinal Chemistry Research
Abstract: Microwave-assisted reactions of triorganotin(IV)/diorganotin(IV) chlorides/oxides with hippuric acid (HHA), in 1:1 or 1:2 molar ratio resulted R<inf>3</inf>Sn(HA) (R = Ph (1b), n-Bu (2b), and Me (3b))/R<inf>2</inf>Sn(HA)<inf>2</inf> (R = n-Oct (4b), n-Bu (5b), and Me (6b)); (HA = anion of hippuric acid). However, all complexes (1a-6a) were also synthesized under conventional thermal conditions for comparison. IR, ESI-MS, and NMR (1H, 13C and 119Sn) spectroscopic studies revealed that R<inf>3</inf>Sn(HA) (1-3) and R<inf>2</inf>Sn(HA)<inf>2</inf> (4, 5) exhibit trigonal-bipyramidal and tetrahedral geometry, respectively (except dimethyltin(IV) hippurate (6) exhibiting octahedral geometry). All complexes (1b-6b) have been screened in vitro against five cancer cell lines of human origin, viz. MCF-7 (mammary cancer), HEK-293 (kidney cancer), PC-3 (prostate cancer), HCT-15 (colon cancer), and HepG-2 (liver cancer). Compounds 1b and 3b exhibited good anti-cancer activity against MCF-7, HEK-293, and PC-3 cell lines, while 6b showed better activity against PC-3 and HepG-2 cell lines. Toxicity and in vivo anti-inflammatory activity of all (1b-6b) complexes in Swiss albino mice have also been carried out. Compound 1b exhibited the highest anti-inflammatory activity among the studied complexes. © 2014 Springer Science+Business Media New York.
Citation: Medicinal Chemistry Research(2015), 24(1): 51-62
Issue Date: 2015
Publisher: Birkhauser Boston
Keywords: Anti-cancer activity
Anti-inflammatory activity
Conventional thermal synthesis
Microwave-assisted synthesis
Organotin(IV) hippurates
ISSN: 10542523
Author Scopus IDs: 7103033909
Author Affiliations: Nath, M., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Vats, M., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Roy, P., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Corresponding Author: Nath, M.; Department of Chemistry, Indian Institute of Technology RoorkeeIndia
Appears in Collections:Journal Publications [BT]
Journal Publications [CY]

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