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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/3490
Title: Donation and scavenging of nitric oxide (NO) by flipping of the denticity of carboxylate ligand in novel ruthenium complexes: Photolability of the coordinated NO
Authors: Ghosh, Kaushik
Kumar S.
Kumar R.
Published in: Inorganica Chimica Acta
Abstract: Novel ruthenium nitrosyl complex [Ru(η1-L 1)(PPh3)2(NO)Cl2] (2) (where L 1H is 3-chlorobenzoic acid and H is dissociable proton) was synthesized and characterized by spectroscopic and electrochemical studies. Molecular structure of complex 2 was determined by X-ray crystallography. The diamagnetic behaviour of 2 was established by NMR spectral studies and redox property of 2 was investigated. DFT optimization of the structure of 2 provided a linear geometry of {RuII-NO+} moiety. The nitrosyl complex acted as novel nitric oxide (NO) donor upon illumination of light and photoreleased NO was trapped by reduced myoglobin. Amount of photolytically cleaved NO was quantified by Griess reagent. The precursor complex [Ru(η2-L1)(PPh3)2Cl 2] (1) was obtained after photorelease of NO and was found to be a potential NO scavenger. Flipping of denticity of carboxylate ligand was observed during NO donation and scavenging. DPPH (2,2-diphenyl-1-picrylhydrazine) radical quenching assay was performed to estimate the amount of generated reactive nitrogen species or/and reactive oxygen species during photolysis of NO. © 2013 Elsevier B.V. All rights reserved.
Citation: Inorganica Chimica Acta (2013), 405(): 24-30
URI: https://doi.org/10.1016/j.ica.2013.04.042
http://repository.iitr.ac.in/handle/123456789/3490
Issue Date: 2013
Publisher: Elsevier S.A.
Keywords: Carboxylate ligand
DPPH quenching study
Griess reaction
NO scavenging activity
Photolability
Ruthenium nitrosyl complex
ISSN: 201693
Author Scopus IDs: 57204513823
7405769266
57208685185
Author Affiliations: Ghosh, K., Department of Chemistry, Indian Institute of Technology, Roorkee, Roorkee 247667, Uttarakhand, India
Kumar, S., Department of Chemistry, Indian Institute of Technology, Roorkee, Roorkee 247667, Uttarakhand, India
Kumar, R., Department of Chemistry, Indian Institute of Technology, Roorkee, Roorkee 247667, Uttarakhand, India
Funding Details: K. G is thankful to CSIR, India for financial assistance (01(2229)/08/EMR-II dated 06-MAR-2008). S. K and R. K are thankful to CSIR for financial support. We are also thankful for FIG-Scheme-B funded by IIT Roorkee. Appendix A
Corresponding Author: Ghosh, K.; Department of Chemistry, Indian Institute of Technology, Roorkee, Roorkee 247667, Uttarakhand, India; email: ghoshfcy@iitr.ernet.in
Appears in Collections:Journal Publications [CY]

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