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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/3059
Title: An Alkaloid from Scorpion Venom: Chemical Structure and Synthesis
Authors: Banerjee S.
Gnanamani E.
Lynch S.R.
Zuñiga F.Z.
Jiménez-Vargas J.M.
Possani L.D.
Zare R.N.
Published in: Journal of Natural Products
Abstract: While most scorpion venom components identified in the past are peptidic or proteinic in nature, we report here a new alkaloid isolated from the venom of the Mexican scorpion Megacormus gertschi. Nuclear magnetic resonance and mass spectrometric investigations elucidate the structure of the alkaloid as (Z)-N-(2-(1H-imidazol-4-yl)ethyl)-3-(4-hydroxy-3-methoxyphenyl)-2-methoxyacrylamide (1). A chemical method of synthesizing this alkaloid is also described. Although abundant in venom, the above alkaloid was not found to have insecticidal activity. Structural analysis suggests that this venom alkaloid might be of potential interest for evaluating its medicinal effect. Copyright © 2018 American Chemical Society and American Society of Pharmacognosy.
Citation: Journal of Natural Products (2018), 81(8): 1899-1904
URI: https://doi.org/10.1021/acs.jnatprod.8b00527
http://repository.iitr.ac.in/handle/123456789/3059
Issue Date: 2018
Publisher: American Chemical Society
ISSN: 1633864
Author Scopus IDs: 37080201400
35319775800
56709241400
57203658531
36170674200
56013752900
35355951800
Author Affiliations: Banerjee, S., Department of Chemistry, Stanford University, Stanford, CA 94305, United States, Indian Institute of Science Education and Research Tirupati, Karakambadi Road, Tirupati, 517507, India
Gnanamani, E., Department of Chemistry, Stanford University, Stanford, CA 94305, United States
Lynch, S.R., Department of Chemistry, Stanford University, Stanford, CA 94305, United States
Zuñiga, F.Z., Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autonoma de Mexico, Avenida Universidad, 2001, Apartado Postal 510-3, Cuernavaca, Morelos, 62210, Mexico
Jiménez-Vargas, J.M., Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autonoma de Mexico, Avenida Universidad, 2001, Apartado Postal 510-3, Cuernavaca, Morelos, 62210, Mexico
Possani, L.D., Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autonoma de Mexico, Avenida Universidad, 2001, Apartado Postal 510-3, Cuernavaca, Morelos, 62210, Mexico
Zare, R.N., Department of Chemistry, Stanford University, Stanford, CA 94305, United States
Corresponding Author: Zare, R.N.; Department of Chemistry, Stanford UniversityUnited States; email: zare@stanford.edu
Appears in Collections:Journal Publications [CY]

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