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dc.contributor.authorGupta B.-
dc.contributor.authorRani M.-
dc.contributor.authorSalunke R.-
dc.contributor.authorKumar R.-
dc.date.accessioned2020-10-06T14:25:31Z-
dc.date.available2020-10-06T14:25:31Z-
dc.date.issued2012-
dc.identifier.citationJournal of Hazardous Materials (2012), 213-214(): 285-291-
dc.identifier.issn3043894-
dc.identifier.other22356742-
dc.identifier.urihttps://doi.org/10.1016/j.jhazmat.2012.01.089-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/2998-
dc.description.abstractA pharmacokinetic in vitro and in vivo degradation study has been carried out in rat to evaluate the deleterious effects of exposure to quinalphos on a target population. Degradation of quinalphos in simulated gastric and intestinal phases has been investigated. The metabolic intermediates of quinalphos in serum and urine of albino rats at different time intervals were identified after dosing the animals with 5mgkg -1 body weight. All the samples were lyophilised, extracted and analysed by HPLC and GC-MS. The rate of degradation of quinalphos was accelerated in the presence of the enzymes pepsin and pancreatin contained in the gastric and intestinal simulations, respectively. Quinalphos oxon, O-ethyl-O-quinoxalin-2-yl phosphoric acid, 2-hydroxy quinoxaline and ethyl phosphoric acid are among the important metabolites identified both in in vitro and in vivo investigations. In simulated in vitro study some isomerised derivatives which were missing in the blood and urine of treated animals were identified. This could possibly be either due to non-formation or faster decay of the isomerised derivatives because of slightly different conditions prevailing in the two cases. The results also indicate that the metabolites, 2-hydroxy quinoxaline and oxon, which are more toxic than the parent compound, seem to persist for a longer time. © 2012.-
dc.language.isoen_US-
dc.relation.ispartofJournal of Hazardous Materials-
dc.subject2-Hydroxyquinoxaline-
dc.subjectDegradation products-
dc.subjectIn vitro-
dc.subjectIn vivo-
dc.subjectQuinalphos-
dc.titleIn vitro and in vivo studies on degradation of quinalphos in rats-
dc.typeArticle-
dc.scopusid7402195167-
dc.scopusid56363756800-
dc.scopusid23991735800-
dc.scopusid55492126800-
dc.affiliationGupta, B., Analytical Laboratory, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667(U.K.), India-
dc.affiliationRani, M., Analytical Laboratory, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667(U.K.), India-
dc.affiliationSalunke, R., Molecular Endocrinology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667(U.K.), India-
dc.affiliationKumar, R., Analytical Laboratory, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667(U.K.), India-
dc.description.fundingThe authors would like to acknowledge Prof. S.N. Tandon (Retired), Former Faculty, Indian Institute of Technology Roorkee, Roorkee –247667(U.K.) India for his valuable suggestions and to Dr. Partha Roy, Associate Professor, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee – 247667(U.K.) India for providing laboratory facility. The authors are highly grateful to Council of Scientific and Industrial Research (CSIR) , India for funding the scheme.-
dc.description.correspondingauthorGupta, B.; Analytical Laboratory, Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667(U.K.), India; email: bvgcyfcy@iitr.ernet.in-
Appears in Collections:Journal Publications [CY]

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