Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2997
Title: Identification of degradation products of thiram in water, soil and plants using LC-MS technique
Authors: Gupta B.
Rani M.
Kumar R.
Dureja P.
Published in: Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes
Abstract: In order to evaluate the deleterious effects of exposure to pesticides on a target population, a comprehensive study on their degradation in the various segments of ecosystem under varying environmental conditions is needed. In view of this, a study has been carried out on the metabolic pathways of thiram, a dithiocarbamate fungicide, in a variety of matrices namely water and soil under controlled conditions and plants in field conditions. The identification of degradation products was carried out in samples collected at various time points using LC-MS. The degradation products identified can be rationalized as originating by a variety of processes like hydrolysis, oxidation, N-dealkylation and cyclization. As a result of these processes the presence of some metabolites like dimethyl dithiocarbamate, bis(dimethyl carbamoyl) disulphide, bis(dimethyl dithiocarbamoyl) trisulphide and N-methyl-amino-dithiocarbamoyl sulphide was observed in all the cases. However, some different metabolites were observed with the change in the matrix or its characteristics such as cyclised products 2(N, N-dimethyl amino)thiazoline carboxylic acid and 2-thioxo-4-thiazolidine were observed only in plants. The investigations reflect that degradation initiates with hydrolysis, subsequently oxidation/dealkylation, followed by different types of reactions. The pathways seem to be complex and dependent on the matrices. Dimethyl dithiocarbamate and oxon metabolites, which are more toxic than parent compound, seem to persist for a longer time. Results indicate persistence vis-a-vis toxicity of pesticide and its metabolites and also provide a data bank of metabolites for forensic and epidemiological investigations. © 2012 Taylor and Francis Group, LLC.
Citation: Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes (2012), 47(8): 823-831
URI: https://doi.org/10.1080/03601234.2012.676487
http://repository.iitr.ac.in/handle/123456789/2997
Issue Date: 2012
Keywords: degradation products
dithiocarbamate
LC-MS
Thiram
ISSN: 3601234
Author Scopus IDs: 7402195167
56363756800
55492126800
7003329145
Author Affiliations: Gupta, B., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee- 247667, India
Rani, M., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee- 247667, India
Kumar, R., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee- 247667, India
Dureja, P., Division of Agricultural Chemicals, Indian Agricultural Research, Institute, New Delhi, India
Funding Details: The authors would like to acknowledge Council of Scientific and Industrial Research (CSIR), India for funding the scheme.
Corresponding Author: Gupta, B.; Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee- 247667, India; email: bvgcyfcy@iitr.ernet.in
Appears in Collections:Journal Publications [CY]

Files in This Item:
There are no files associated with this item.
Show full item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.