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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2834
Title: Evaluation of volumetric mass transfer coefficient in a stirred tank bioreactor using response surface methodology
Authors: Lone S.R.
Kumar V.
Seay J.R.
Englert D.L.
Hwang H.T.
Published in: Environmental Progress and Sustainable Energy
Abstract: Stirred tank reactors are most commonly used both in the laboratory and industry. Particularly for bioreactors, the volumetric mass transfer coefficient (k L a) of oxygen is used as one of the important parameters for determining efficiencies of reactors and for successful scale-up. A number of correlation methods have been previously developed to predict the k L a in stirred tank bioreactors. In the present work, we propose a new correlation for k L a based on a mathematical and statistical approach using Response Surface Methodology (RSM) based on Box-Behnken design of experiments. This correlation includes the effect of various parameters such as impeller agitation rate (50–800 rpm), air flow rate (0.5–3.5 L/min), and temperature (10?40°C) for different impeller configurations (single and dual Rushton, pitched blade, and mixed turbines). It was observed that the k L a increases with increasing the parameters for all the impeller configurations studied. Among the operating parameters, the most significant variable impacting k L a was found to be agitation rate, followed by air flow rate, and temperature. The models developed using RSM successfully interpreted the experimental k L a and were further validated under other operating conditions. It was also found that, compared with conventional power-law models, the RSM approach enables a more efficient correlation procedure and formulates simplified models with comparably high accuracy, suggesting that the RSM is promising for evaluation of oxygen mass transfer in stirred tank bioreactors. © 2018 American Institute of Chemical Engineers Environ Prog, 38: 387–401, 2019. © 2018 American Institute of Chemical Engineers
Citation: Environmental Progress and Sustainable Energy (2019), 38(2): 387-401
URI: https://doi.org/10.1002/ep.12973
http://repository.iitr.ac.in/handle/123456789/2834
Issue Date: 2019
Publisher: John Wiley and Sons Inc.
Keywords: Box-Behnken design
gas–liquid system
mass transfer coefficient
response surface methodology
stirred tank bioreactor
ISSN: 19447442
Author Scopus IDs: 57204113695
7404634425
25928741600
57208037748
57204105179
Author Affiliations: Lone, S.R., Department of Chemical Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India, Department of Chemical & Materials Engineering, University of Kentucky, 4810 Alben Barkley Drive, Paducah, KY, United States
Kumar, V., Department of Chemical Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India
Seay, J.R., Department of Chemical & Materials Engineering, University of Kentucky, 4810 Alben Barkley Drive, Paducah, KY, United States
Englert, D.L., Department of Chemical & Materials Engineering, University of Kentucky, 4810 Alben Barkley Drive, Paducah, KY, United States
Hwang, H.T., Department of Chemical & Materials Engineering, University of Kentucky, 4810 Alben Barkley Drive, Paducah, KY, United States
Funding Details: This work was supported jointly by the University of Kentucky – Indian Institute of Technology Roorkee collaborative research program. The authors also acknowledge the financial assistance by the Ministry of Human Resource Development (MHRD), Government of India.
Corresponding Author: Hwang, H.T.; Department of Chemical & Materials Engineering, University of Kentucky, 4810 Alben Barkley DriveUnited States; email: hyun-tae.hwang@uky.edu
Appears in Collections:Journal Publications [CH]

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