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Title: Kinetic modeling and sensitivity analysis of kinetic parameters for L-glutamic acid production using Corynebacterium glutamicum
Authors: Suresh S.
Khan N.S.
Srivastava, Vimal Chandra
Mishra I.M.
Published in: International Journal of Chemical Reactor Engineering
Abstract: In the present work, a kinetic model has been developed for the batch fermentation of glucose for the production of L-glutamic acid (LGA) by Corynebacterium glutamicum. Parameters of the kinetic model have been determined by using the experimental data available in literature and the results have been compared by carrying out computer simulation. The kinetic model proposed in the present study provides better predictions for the growth of biomass, substrate consumption and LGA production as compared to the prediction reported by Bona and Moser (Bioprocess Engineering 17(2) (1997b) 121-125). The present model also fits the experimental data given by Zhang et al. (Enzyme and Microbial Technology, 22, 205-209, 1998) and Khan et al. (Biochemical Engineering Journal, 25, 173-178, 2005), respectively. Sensitivity analysis was carried out to assess the validity of the developed model, and to reveal the kinetic parameter that has maximum impact on LGA production. It is found that an increase in the non-growth associated product formation coefficient caused highest negative impact on LGA production. Copyright © 2009 The Berkeley Electronic Press. All rights reserved.
Citation: International Journal of Chemical Reactor Engineering (2009), 7(): -
Issue Date: 2009
Keywords: Biomass
Corynebacterium glutamicum
L-glutamic acid
Sensitivity analysis
ISSN: 15426580
Author Scopus IDs: 22935957500
Author Affiliations: Suresh, S., Indian Institute of Technology Roorkee, India
Khan, N.S., National Institute of Technology, Srinagar, India
Srivastava, V.C., Indian Institute of Technology Roorkee, India
Mishra, I.M., National Institute of Technology, Srinagar, India
Corresponding Author: Suresh, S.; Indian Institute of Technology RoorkeeIndia; email:
Appears in Collections:Journal Publications [CH]

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