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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2560
Title: Mixture solubilities of nitrobenzoic acid isomers in supercritical carbon dioxide
Authors: Reddy, Sivamohan N.
Madras G.
Published in: Journal of Supercritical Fluids
Abstract: The ternary solubilities of solid isomers of nitrobenzoic acid (NBA) were experimentally determined at 308, 318 and 328 K over a pressure range of 12-18 MPa in supercritical carbon dioxide (SCCO 2). Compared to its binary solubility, the ternary solubilities of m-NBA increased at 308 K while it decreased at 328 K. However, the ternary solubilities of p-NBA increased at all temperatures and pressures except at 13 MPa and 328 K. A new model was developed by applying solution model and activity coefficient model for the ternary solubilities of pharmaceutical and non-pharmaceutical solid mixtures in terms of temperature, density and cosolute composition. The model equation involves four temperature independent constraint-free parameters. The model equation correlates the ternary solubilities of seven pharmaceutical solid mixtures along with current data with an average AARD around 9.5% and sixteen non-pharmaceutical solid mixtures with 9% AARD. © 2012 Elsevier B.V.
Citation: Journal of Supercritical Fluids (2012), 70(): 66-74
URI: https://doi.org/10.1016/j.supflu.2012.06.012
http://repository.iitr.ac.in/handle/123456789/2560
Issue Date: 2012
Keywords: Activity coefficient model
Cosolute composition
Nitrobenzoic acid isomers
Pharmaceutical solid mixtures
Solution model
Ternary solubilities
ISSN: 8968446
Author Scopus IDs: 56923787200
7005905149
Author Affiliations: Reddy, S.N., Department of Chemical Engineering, Indian Institute of Science, Bangalore 560012, India
Madras, G., Department of Chemical Engineering, Indian Institute of Science, Bangalore 560012, India
Funding Details: The authors thank the Council for Scientific and Industrial Research (CSIR) for financial support.
Corresponding Author: Madras, G.; Department of Chemical Engineering, Indian Institute of Science, Bangalore 560012, India; email: giridhar@chemeng.iisc.ernet.in
Appears in Collections:Journal Publications [CH]

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