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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2542
Title: Neuroprotective potential of Cucurbita maxima Duchesne ex Poir, Caeselpenia bunduc (L.) Roxb and Bombax ceiba Linn extracts
Authors: Sinha, Shishir N.
Kumar B.
Luqman S.
Singh D.K.
Published in: South African Journal of Botany
Abstract: Plant derived molecules are gaining importance as an alternative to synthetic drugs for the treatment of cognitive and related disorders. Modulation of cholinesterases, monoamine oxidases and sodium–potassium ATPase activities in brain through phyto-molecules has been found effective in the treatment and management of cognitive disorders. Considering the pleiotropic action of plant secondary metabolites, the present investigation was undertaken to explore neuroprotective activity of the ethanolic and hexane extracts from Cucurbita maxima Duchesne ex Poir (seeds), Caeselpenia bunduc (L.) Roxb (seeds) and Bombax ceiba Linn (flowers). To investigate the neuroprotective activity of these plant extracts, cholinesterases (acetylcholinesterase and butyrylcholinesterase), monoamine oxidase (MAO) and Na + /K + ATPase activities were estimated. To test if chosen plant extracts have also effect on oxidative stress lipid peroxidation and metal chelating ability were determined in mice brain homogenate. In this investigation the ethanolic and hexane extracts from these plants were able to inhibit the acetylcholinesterase and butyrylcholinesterase (43.32–69.94%), which was comparable to standard drug, donepezil at the concentration of 50 ?g/ml. The chromatographic (HPTLC) estimation revealed the maximum presence of quercetin in C. maxima whereas p-coumaric acid and gallic acid were found as major constituents in B. ceiba. In conclusion, the findings of current study provide evidence for the selected plant extracts with potent cholinesterase activity which can be taken as lead for further mechanistic study and also for development of plant based formulation after pre-clinical evaluation. © 2018 South African Association of Botanists
Citation: South African Journal of Botany (2019), 120(): 319-325
URI: https://doi.org/10.1016/j.sajb.2018.09.027
http://repository.iitr.ac.in/handle/123456789/2542
Issue Date: 2019
Publisher: Elsevier B.V.
Keywords: Bombax ceiba
Caeselpenia bunduc
Cholinesterase
Cucurbita maxima
Na + /K + ATPase
ISSN: 2546299
Author Scopus IDs: 7403739121
56386643200
55912423700
57189076641
Author Affiliations: Sinha, S., Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India
Kumar, B., Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India
Luqman, S., Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, 226015, India
Singh, D.K., Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, 226015, India, Sackler School of Medicine, Tel Aviv University, Israel
Funding Details: We are grateful to Director, Institute of Medicinal Sciences (IMS) and Head of Pharmacology Department, BHU, Varanasi for rendering research facilities. SS is thankful to UGC , New Delhi for granting Junior Research Fellowship (JRF) for her Ph.D.
Corresponding Author: Singh, D.K.; Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic PlantsIndia; email: dhananjas@mail.tau.il
Appears in Collections:Journal Publications [CH]

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