http://repository.iitr.ac.in/handle/123456789/25260| Title: | Synthesis and antiamoebic activity of new cyclooctadiene ruthenium(II) complexes with 2-acetylpyridine and benzimidazole derivatives |
| Authors: | Bharti N. Maurya, Mannar Ram Naqvi F. Azam A. |
| Published in: | Bioorganic and Medicinal Chemistry Letters |
| Abstract: | Reaction of [Ru(η4-C8H12) (CH3CN)2 Cl2] with 2-(2-pyridyl) benzimidazole or Schiff bases derived from 2-acetylpyridine and S-methyldithiocarbazate, S-benzyldithiocarbazate and thiosemicarbazide leads to form new complexes of the type [Ru(η4-C8H12)(L)Cl2] (where L = ligand). In vitro, most of the compounds exhibited potent activity and the Ru derivatives 1a [Ru(η4-C8H12)(2-Acpy-SMDT)Cl2], 2a [Ru(η4-C8H12)(2-Acpy-SBDT)Cl2] and 3a [Ru(η4-C8H12)(2-Acpy-TSC)Cl2] were found more active than metronidazole against (HK-9) strain of Entamoeba histolytica. (C) 2000 Elsevier Science Ltd. |
| Citation: | Bioorganic and Medicinal Chemistry Letters, 10(20): 2243-2245 |
| URI: | https://doi.org/10.1016/S0960-894X(00)00446-7 http://repository.iitr.ac.in/handle/123456789/25260 |
| Issue Date: | 2000 |
| Keywords: | alkadiene antiamebic agent benzimidazole derivative metronidazole pyridine derivative ruthenium complex amebiasis antiprotozoal activity drug mechanism drug synthesis Entamoeba histolytica nonhuman Amebicides Animal Benzimidazoles Entamoeba histolytica Indicators and Reagents Organometallic Compounds Pyridines Rhodium Schiff Bases Structure-Activity Relationship Support, Non-U.S. Gov't |
| ISSN: | 0960894X |
| Author Scopus IDs: | 6604010443 7005255411 6602084375 7004380175 |
| Author Affiliations: | Bharti, N., Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110 025, India Maurya, M.R., Department of Chemistry, University of Roorkee, Roorkee 246776, U.P., India Naqvi, F., Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110 025, India Azam, A., Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110 025, India |
| Funding Details: | N. Bharti acknowledges the senior research fellowship from CSIR, New Delhi, India. The authors thank Prof. Alok Bhattacharya, and Dr. Sudha Bhattacharya, Jawaharlal Nehru University, New Delhi for providing laboratory facilities for biological studies. Council of Scientific and Industrial Research, India, CSIR |
| Corresponding Author: | Azam, A.; Department of Chemistry, Jamia Nagar, New Delhi 110 025, India |
| Appears in Collections: | Journal Publications [CY] |
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