Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/25161
Title: A study of DNA/BSA interaction and catalytic potential of oxidovanadium(v) complexes with ONO donor ligands
Authors: DashThese Authors Contributed Equally To This Work S.P.
Panda A.K.
Dhaka S.
Pasayat S.
Biswas A.
Maurya, Mannar Ram
Majhi P.K.
Crochet A.
Dinda R.
Published in: Dalton Transactions
Abstract: The study of DNA/BSA interaction and the catalytic potential of four mononuclear oxidoalkoxido vanadium(v) [VVO(L1-4)OEt] (1-4) and one dinuclear oxidoalkoxido mixed-ligand vanadium(v) [{VO(L2)OEt}2(Q)]{Q = 4,4′-bipyridine}(5) complexes, with tridentate binegative aroylazine ligands are reported [where H2L1 = anthranylhydrazone of 2-hydroxy-1-napthaldehyde, H2L2 = salicylhydrazone of 2-hydroxy-1-napthaldehyde, H2L3 = benzoylhydrazone of 2-hydroxy-1-acetonaphthone, H2L4 = anthranylhydrazone of 2-hydroxy-1-acetonaphthone]. All the complexes are characterized by elemental analysis as well as various spectroscopic techniques. Single crystal X-ray diffraction crystallography of 2 reveals that the metal centre is in distorted square pyramidal geometry with O4N coordination spheres, whereas 5 exhibits a distorted octahedral geometry around the metal center. In addition, all the complexes (1-5) show moderate DNA binding propensity which is investigated using UV-vis absorption titration, circular dichroism, thermal denaturation and fluorescence spectral studies. The experimental results show that the complexes effectively interact with CT-DNA through both minor and major groove binding modes, with binding constants ranging from 104105 M1. Among 1-5, complexes 3 and 4 show higher binding affinity towards CT-DNA than others and at the same time also exhibit negative ΔTm values of about ∼1.5 and 1.0 °C which resembles the properties shown by cisplatin. All complexes show moderate photo-induced cleavage of pUC19 supercoiled plasmid DNA with complex 3 showing the highest photo induced DNA cleavage activity of ∼48%. In coherence with the DNA interaction studies, 3 and 4 also exhibit good binding affinity towards BSA in the range of 10101011 M1, which is also supported by their ability to quench the tryptophan fluorescence emission spectra of BSA. All the complexes show remarkable photo-induced BSA cleavage activity (>90%) at a complex concentration of 50 μM. The catalytic potential of 1-5 is also tested for the oxidative bromination of styrene, salicylaldehyde and oxidation of methyl phenyl sulphide. All the reactions show a high percentage of conversion (>90%) with a high turnover frequency (TOF). Particularly, in the oxidative bromination of styrene the percentage of conversion and TOF vary from 96-98% and 8000-19600 (h1) respectively, which signifies the potential of these oxidovanadium(v) complexes to stimulate research for the synthesis of a better catalyst. © The Royal Society of Chemistry.
Citation: Dalton Transactions, 45(45): 18292-18307
URI: https://doi.org/10.1039/c6dt03228a
http://repository.iitr.ac.in/handle/123456789/25161
Issue Date: 2016
Publisher: Royal Society of Chemistry
Keywords: Amino acids
Binding energy
Bins
Catalytic oxidation
Dichroism
DNA
Emission spectroscopy
Fluorescence
Ligands
Platinum compounds
Single crystals
Spectroscopic analysis
Styrene
Synthesis (chemical)
Vanadium compounds
X ray crystallography
X ray diffraction
Complex concentration
Groove binding modes
Oxidative bromination
Single crystal x-ray diffraction
Spectroscopic technique
Square-pyramidal geometry
Thermal denaturations
Tryptophan fluorescence
Complexation
1-acetonaphthone
4,4'-bipyridyl
aldehyde
bovine serum albumin
calf thymus DNA
DNA
naphthalene derivative
organometallic compound
protein binding
pyridine derivative
salicylaldehyde
styrene
vanadium
catalysis
chemistry
circular dichroism
DNA cleavage
nuclear magnetic resonance spectroscopy
photochemistry
synthesis
X ray crystallography
Aldehydes
Catalysis
Circular Dichroism
Crystallography, X-Ray
DNA
DNA Cleavage
Magnetic Resonance Spectroscopy
Naphthalenes
Organometallic Compounds
Photochemical Processes
Protein Binding
Pyridines
Serum Albumin, Bovine
Styrene
Vanadium
ISSN: 14779226
Author Scopus IDs: 57192009745
54581436700
55660503000
36933840100
7202059636
7005255411
36976197600
36097678500
6602401800
Author Affiliations: DashThese Authors Contributed Equally To This Work, S.P., Department of Chemistry, National Institute of Technology, Rourkela,Odisha, 769008, India, Department of Chemistry, Kuchinda College, Kuchinda, Sambalpur, 768222, India
Panda, A.K., School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar,Odisha, 751 013, India
Dhaka, S., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Pasayat, S., Department of Chemistry, National Institute of Technology, Rourkela,Odisha, 769008, India
Biswas, A., School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar,Odisha, 751 013, India
Maurya, M.R., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Majhi, P.K., Department of Chemistry, National Institute of Technology, Rourkela,Odisha, 769008, India, Institute for Chemical Research, Kyoto University, Gokasho Uji, Kyoto, 611-0011, Japan
Crochet, A., Fribourg Center for Nanomaterials, Department of Chemistry, University of Fribourg, Fribourg, CH-1700, Switzerland
Dinda, R., Department of Chemistry, National Institute of Technology, Rourkela,Odisha, 769008, India
Funding Details: Funding for this research was provided by the Department of Science and Technology, India [grant SR/WOS-A/CS-145/2011 (SPD), grant SR/FT/CS-016/2008 (RD)] and the Council of Scientific and Industrial Research, India [grant 37(1535)/12/EMR-II) (AB)]. AKP acknowledges the receipt of a fellowship from ICMR, India [grant 45/25/2012-Bio/BMS]. Department of Science and Technology, Ministry of Science and Technology, India, डीएसटी: SR/FT/CS-016/2008, SR/WOS-A/CS-145/2011; Indian Council of Medical Research, ICMR: 45/25/2012-Bio/BMS; Council of Scientific and Industrial Research, India, CSIR: 37(1535)/12/EMR-II
Corresponding Author: Dinda, R.; Department of Chemistry, India; email: rupamdinda@nitrkl.ac.in
Appears in Collections:Journal Publications [CY]

Files in This Item:
There are no files associated with this item.
Show full item record


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.