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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/24758
Title: Bio-extract amalgamated sodium alginate-cellulose nanofibres based 3D-sponges with interpenetrating BioPU coating as potential wound care scaffolds
Authors: Yadav C.
Chhajed M.
Choudhury P.
Sahu R.P.
Patel A.
Chawla S.
Goswami L.
Goswami C.
Li X.
Agrawal A.K.
Saini A.
Maji, Pradip K.
Published in: Materials Science and Engineering C
Abstract: In this work, sodium alginate (SA) based “all-natural” composite bio-sponges were designed for potential application as wound care scaffold. The composite bio-sponges were developed from the aqueous amalgamation of SA and cellulose nanofibres (CNFs) in bio-extracts like Rice water (Rw) and Giloy extract (Ge). These sponges were modified by employing a simple coating strategy using vegetable oil-based bio-polyurethane (BioPU) to tailor their physicochemical and biological properties so as to match the specific requirements of a wound care scaffold. Bio-sponges with shared interpenetrating polymeric network structures were attained at optimized BioPU coating formulation. The interpenetration of BioPU chains within the sponge construct resulted in the formation of numerous micro-networks in the interconnected microporous structure of sponges (porosity ≥75%). The coated sponge showed a superior mechanical strength (compressive strength ~3.8 MPa, compressive modulus ~35 MPa) with appreciable flexibility and recoverability under repeated compressive loading-unloading cycles. A tunable degradation behaviour was achieved by varying BioPU coating concentrations owing to the different degree of polymer chain entanglement within the sponge construct. The physical entanglement of BioPU chains with core structural components of sponge improved their structural stability by suppressing their full fragmentation in water-based medium without affecting its swelling behaviour (swelling ratio > 1000%). The coated sponge surface has provided a suitable moist-adherent physical environment to support the adhesion and growth of skin cells (HaCaT cells). The MTT (3-(4,5-dimethyl thiazolyl-2)-2,5-diphenyltetrazolium bromide) assay and hemolytic assay revealed the non-toxic and biocompatible nature of coated sponges in vitro. Moreover, no signs of skin erythema or edema were observed during in vivo dermal irritation and corrosion test performed on the skin of Sprague Dawley (SD) rats. Our initial observations revealed the credibility of these sponges as functional wound care scaffolds as well as its diverse potential as a suitable substrate for various tissue engineering applications. © 2020 Elsevier B.V.
Citation: Materials Science and Engineering C, 118
URI: https://doi.org/10.1016/j.msec.2020.111348
http://repository.iitr.ac.in/handle/123456789/24758
Issue Date: 2021
Publisher: Elsevier Ltd
Keywords: Bio-polyurethane (BioPU)
Biocompatibility
Cellulose nanofibres
Scaffold
Wound care
ISSN: 9284931
Author Scopus IDs: 57193354539
57210960710
57191596553
57218602194
57218600878
55839292300
36887214600
8236317400
27168857700
35615226500
57193361372
56249287900
Author Affiliations: Yadav, C., Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, China, Indian Institute of Technology Roorkee, Department of Polymer and Process Engineering, Saharanpur Campus, Saharanpur, U.P. 247001, India
Chhajed, M., Indian Institute of Technology Roorkee, Department of Polymer and Process Engineering, Saharanpur Campus, Saharanpur, U.P. 247001, India
Choudhury, P., School of Biotechnology, Kalinga Institute of Industrial Technology, Patia, Bhubaneswar, 751024, India
Sahu, R.P., School of Biological Sciences, National Institute of Science Education and Research, HBNI, Jatni, Khordha, Odisha 752050, India
Patel, A., Department of Materials Science and Engineering, Indian Institute of Technology Delhi, New Delhi, 110016, India
Chawla, S., School of Biological Sciences, National Institute of Science Education and Research, HBNI, Jatni, Khordha, Odisha 752050, India
Goswami, L., School of Biotechnology, Kalinga Institute of Industrial Technology, Patia, Bhubaneswar, 751024, India
Goswami, C., School of Biological Sciences, National Institute of Science Education and Research, HBNI, Jatni, Khordha, Odisha 752050, India
Li, X., Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, China
Agrawal, A.K., Technical Physics Division, Bhabha Atomic Research Centre, Mumbai, India
Saini, A., Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, China
Maji, P.K., Indian Institute of Technology Roorkee, Department of Polymer and Process Engineering, Saharanpur Campus, Saharanpur, U.P. 247001, India
Funding Details: This research project has been supported by the Science and Engineering Research Board, Govt of India, under the Early Career Research Award (Grant No. ECR/2016/000621/CS) and National Natural Science Foundation of China (31370578), College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology. The author Chandravati is thankful to NISER animal house staff; Suchismita Mohanty, Sibabrata Sarangi, Kuna Meher and Surendra Kumar Dora (NISER, Bhubaneshwar, India), for their help. The authors also thank Mr. Deepak Sharma, Forest Research Institute, Dehradun, India, for his technical assistance related to XRD. National Natural Science Foundation of China, NSFC: 31370578; Science and Engineering Research Board, SERB: ECR/2016/000621/CS; Shaanxi University of Science and Technology, SUST; National Institute of Science Education and Research, NISER
Corresponding Author: Yadav, C.; Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, China; email: 4495@sust.edu.cn Maji, P.K.; Indian Institute of Technology Roorkee, Saharanpur Campus, India; email: pradip.fpt@iitr.ac.in
Appears in Collections:Journal Publications [PE]

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