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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/24741
Title: Whey protein based electrosprayed nanospheres for encapsulation and controlled release of bioactive compounds from Tinospora cordifolia extract
Authors: Jain A.
Dasgupta N.
Ranjan S.
Singh V.
Singh H.
Purohit S.D.
Mishra, Narayan Chandra
Yadav N.P.
Haque S.
Mishra B.N.
Samanta S.K.
Published in: Innovative Food Science and Emerging Technologies
Abstract: The synergistic effects of bioactive compounds of Tinospora cordifolia have insulin mimicking and hypoglycemic activity, however, low bioavailability and poor stability limits its potential. In the present study, an appropriate delivery system was developed for the controlled release of its anti-diabetic activity. The bioactive compounds such as palmatine, berberine and palmatoside had better binding energy as observed in docking studies compared to that of the commercial active compounds. However, as these biocompounds from Tinospora cordifolia are associated with low stability and poor bioavailability, these compounds were encapsulated in a core-shell matrix of whey protein isolate. The bioactive compounds had highest antidiabetic activity in chloroform extract with an IC50 concentration of 11.34 mg/ml. An increase in 28.12% activity was observed in nanoemulsion form with an average size of 82.68 ± 4.37 nm. The bioactive compounds were further encapsulated by electrospray technique for increased stability. The particles had an encapsulation efficiency of 91.2 ± 3.27% with an average particle size of 187 ± 2.71 nm. The kinetic study revealed the complete release of bioactive compounds after 24 h of incubation in buffer solution. This formulation can be further explored as novel nutraceutical delivery system with minimal side effects as compared to their synthetic counterparts. Considering the potential application of this developed technology, further upscaling as well as in-vivo experimentation on small as well as large animals should be performed. © 2021 Elsevier Ltd
Citation: Innovative Food Science and Emerging Technologies, 69
URI: https://doi.org/10.1016/j.ifset.2021.102671
http://repository.iitr.ac.in/handle/123456789/24741
Issue Date: 2021
Publisher: Elsevier Ltd
Keywords: Antidiabetic
Electrospray
Encapsulation
Nanoemulsion
Tinospora cordifolia
ISSN: 14668564
Author Scopus IDs: 57225972659
56029772200
56030427200
57207729183
57222641147
57209288373
36798999600
25222172600
35793732800
56018900900
23669129200
Author Affiliations: Jain, A., Department of Biotechnology, Institute of Engineering and Technology, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India
Dasgupta, N., Department of Biotechnology, Institute of Engineering and Technology, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India
Ranjan, S., Faculty of Engineering and the Built Environment, University of Johannesburg, Johannesburg, South Africa
Singh, V., Department of Biotechnology, Institute of Engineering and Technology, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India
Singh, H., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, India
Purohit, S.D., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, India
Mishra, N.C., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, India
Yadav, N.P., CSIR-Central Institute of Medicinal & Aromatic Plants, Lucknow, Uttar Pradesh, India
Haque, S., Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan, 45142, Saudi Arabia
Mishra, B.N., Department of Biotechnology, Institute of Engineering and Technology, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India
Samanta, S.K., Department of Chemical and Biochemical Engineering, Indian Institute of Technology Patna, Bihta, Patna, Bihar, India
Corresponding Author: Dasgupta, N.; Department of Biotechnology, India; email: nanditadg254@gmail.com
Appears in Collections:Journal Publications [PE]

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