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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/24737
Title: Microdesigned Nanocellulose-Based Flexible Antibacterial Aerogel Architectures Impregnated with Bioactive Cinnamomum cassia
Authors: Saini A.
Yadav C.
Sethi S.K.
Xue B.-L.
Xia Y.
Li K.
Manik, Gaurav
Li X.
Published in: ACS Applied Materials and Interfaces
Abstract: This work is strategically premeditated to study the potential of a herbal medicinal product as a natural bioactive ingredient to generate nanocellulose-based antibacterial architectures. In situ fibrillation of purified cellulose was done in cinnamon extract (ciE) to obtain microfibrillated cellulose (MFC). To this MFC suspension, carboxylated cellulose nanocrystals (cCNCs) were homogeneously mixed and the viscous gel thus obtained was freeze-dried to obtain lightweight and flexible composite aerogel architectures impregnated with ciE, namely, ciMFC/cCNCs. At an optimal concentration of 0.3 wt % cCNCs (i.e., for ciMFC/cCNCs_0.3), an improvement of around 106% in compressive strength and 175% increment in modulus were achieved as compared to pristine MFC architecture. The efficient loading and interaction of ciE components, specifically cinnamaldehyde, with MFC and cCNCs resulted in developing competent antibacterial surfaces with dense and uniform microstructures. Excellent and long-term antimicrobial activity of the optimized architectures (ciMFC/cCNCs_0.3) was confirmed through various antibacterial assays like the zone inhibition method, bacterial growth observation at OD600, minimum inhibitory concentration (MIC, here 1 mg/mL), minimum bactericidal concentration (MBC, here 3-5 mg/mL), and Live/Dead BacLight viability tests. The changes in the bacterial morphology with a disrupted membrane were further confirmed through various imaging techniques like confocal laser scanning microscopy, FESEM, AFM, and 3D digital microscopy. The dry composite architecture showed the persuasive capability of suppressing the growth of airborne bacteria, which in combination with antibacterial efficiency in the wet state is considered as an imperative aspect for a material to act as the novel biomaterial. Furthermore, these architectures demonstrated excellent antibacterial performance under real "in use"contamination prone conditions. Hence, this work provides avenues for the application of crude natural extracts in developing novel forms of advanced functional biomaterials that can be used for assorted biological/healthcare applications such as wound care and antimicrobial filtering units. ©
Citation: ACS Applied Materials and Interfaces, 13(4): 4874-4885
URI: https://doi.org/10.1021/acsami.0c20258
http://repository.iitr.ac.in/handle/123456789/24737
Issue Date: 2021
Publisher: American Chemical Society
Keywords: antibacterial architectures
cinnamaldehyde
cinnamon extract (ciE)
nanocellulose
ISSN: 19448244
Author Scopus IDs: 57193361372
57193354539
57198345541
53464571100
57221800446
57221803878
56595314900
27168857700
Author Affiliations: Saini, A., Shaanxi Provincial Key Laboratory of Papermaking Technology, Specialty Paper Development, College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, 710021, China
Yadav, C., Shaanxi Provincial Key Laboratory of Papermaking Technology, Specialty Paper Development, College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, 710021, China
Sethi, S.K., Department of Polymer and Process Engineering, IIT Roorkee Saharanpur Campus, Saharanpur, Uttar Pradesh, 247001, India
Xue, B.-L., Shaanxi Provincial Key Laboratory of Papermaking Technology, Specialty Paper Development, College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, 710021, China
Xia, Y., Shaanxi Provincial Key Laboratory of Papermaking Technology, Specialty Paper Development, College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, 710021, China
Li, K., Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Shaanxi Key Laboratory of Brain Disorders, Institute of Basic and Translational Medicine, Xi'An Medical University, Xi'an, Shaanxi, 710021, China
Manik, G., Department of Polymer and Process Engineering, IIT Roorkee Saharanpur Campus, Saharanpur, Uttar Pradesh, 247001, India
Li, X., Shaanxi Provincial Key Laboratory of Papermaking Technology, Specialty Paper Development, College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, 710021, China
Funding Details: This work was supported by the National Natural Science Foundation of China (31370578) and Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology. The authors kindly acknowledge the help from Ms. Xuelian Wang, Ms. Chen Lihong, and Mr. Jia Shuntian (Shaanxi University of Science and Technology) for technical assistance. The authors would also like to thank Mr. Uday Shankar (IIT Roorkee) for his guidance in modeling and simulation studies. National Natural Science Foundation of China, NSFC: 31370578; Shaanxi University of Science and Technology, SUST
Corresponding Author: Yadav, C.; Shaanxi Provincial Key Laboratory of Papermaking Technology, China; email: 4495@sust.edu.cn Li, X.; Shaanxi Provincial Key Laboratory of Papermaking Technology, China; email: lixp@sust.edu.cn
Appears in Collections:Journal Publications [PE]

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