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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2400
Title: Molecular Insights into the Effects of Media-Drug and Carrier-Drug Interactions on pH-Responsive Drug Carriers
Authors: Katiyar R.S.
Jha, Prateek K.
Published in: Molecular Pharmaceutics
Abstract: We have performed two sets of all atom molecular dynamics (MD) simulations of poly(acrylic acid) (PAA) oligomers, considered as a model pH-responsive drug carrier. In the first set, multiple oligomers of PAA are simulated in model gastric and intestinal fluids, where the degree of deprotonation of PAA oligomers is varied with the medium pH. Since the gastric fluid has a pH substantially lower than that of intestinal fluid, PAA is relatively lesser ionized in gastric fluid and forms aggregates. In the second set, we simulated multiple oligomers of PAA with multiple molecules of a cationic anticancer drug, doxorubicin (DOX), for a range of pH values representative of various physiological conditions. The diffusion coefficient of DOX decreases with an increase in pH due to an increase in the ionic complexation of PAA with DOX, despite a decrease in PAA aggregation. Our findings are in agreement with recent experimental reports on pH-triggered targeting of tumor cells by the PAA-DOX system. Results of these two sets of studies establish that both carrier aggregation and carrier-drug interactions are competing influences that together determine the drug release from pH-responsive polymers. © 2018 American Chemical Society.
Citation: Molecular Pharmaceutics (2018), 15(6): 2479-2483
URI: https://doi.org/10.1021/acs.molpharmaceut.8b00151
http://repository.iitr.ac.in/handle/123456789/2400
Issue Date: 2018
Publisher: American Chemical Society
Keywords: cancer
controlled release
diffusion
macromolecular drug delivery
molecular dynamics
pH
pharmacokinetics
polyelectrolytes
polymeric drug carrier
simulations
ISSN: 15438384
Author Scopus IDs: 56157437800
36672956500
Author Affiliations: Katiyar, R.S., Department of Chemical Engineering, IIT Roorkee, Roorkee, Uttarakhand, 247667, India
Jha, P.K., Department of Chemical Engineering, IIT Roorkee, Roorkee, Uttarakhand, 247667, India
Funding Details: This work is supported by a research grant from the Science and Engineering Research Board (SERB), India (no. YSS/ 2015/001228).
Corresponding Author: Jha, P.K.; Department of Chemical Engineering, IIT RoorkeeIndia; email: pkjchfch@iitr.ac.in
Appears in Collections:Journal Publications [CH]

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