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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2335
Title: Semiinterpenetrating polymer networks of chitosan and L-alanine for monitoring the release of chlorpheniramine maleate
Authors: Kumari K.
Kundu P.P.
Published in: Journal of Applied Polymer Science
Abstract: In vitro studies have been carried on semiinterpenetrating polymer network (IPN) beads of chitosanalanine as carrier for the controlled release of chlorpheniramine maleate (CPM) drug. A viscous solution of chitosanalanine was prepared in 2% acetic acid solution, extruded as droplets by a syringe to NaOH-methanol solution and crosslinked using glutaraldehyde as a crosslinker. The swelling behavior of crosslinked beads in different pH solutions was measured at different time intervals. The swelling behavior was observed to be dependent on pH and degree of crosslinking. The structural and morphological studies of beads were carried out by using a scan-ning electron microscope. The drug release experiments of different drug loading capacity beads were performed in solutions of pH 2 and pH 7.4 using CPM as a model drug. The concentration of the released drug was evaluated using UV spectrophotometer. The results suggest that chitosan-alanine crosslinked beads are suitable for controlled release of drug. © 2006 Wiley Periodicals, Inc.
Citation: Journal of Applied Polymer Science (2007), 103(6): 3751-3757
URI: https://doi.org/10.1002/app.25432
http://repository.iitr.ac.in/handle/123456789/2335
Issue Date: 2007
Keywords: Alanine
Beads
Chitosan
Controlled drug release
Crosslinking
Interpenetrating polymer networks
Swelling
ISSN: 218995
Author Scopus IDs: 57198199454
35475516300
Author Affiliations: Kumari, K., Department of Chemical Technology, Sant Longowal Institute of Engineering and Technology, Longowal 148106, India
Kundu, P.P., Department of Chemical Technology, Sant Longowal Institute of Engineering and Technology, Longowal 148106, India
Corresponding Author: Kundu, P.P.; Department of Chemical Technology, Sant Longowal Institute of Engineering and Technology, Longowal 148106, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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