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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2304
Title: Strategies for effective oral insulin delivery with modified chitosan nanoparticles: A review
Authors: Mukhopadhyay P.
Mishra R.
Rana D.
Kundu, Patit Paban
Published in: Progress in Polymer Science
Abstract: Over the last few decades, various natural polymers have been applied to the problem of oral insulin delivery using advanced nanotechnology. Parenteral administration of insulin is widely accepted, but administration via the oral route could overcome the poor patient compliance with repeated injection. Polymers from natural as well as synthetic sources have recently been used in the synthesis of insulin delivery vehicles suitable for oral administration. The biopolymer chitosan has been widely studied in oral insulin delivery due to its favorable properties such as biocompatibility, biodegradability, non-immunogenicity and non-toxicity. This review focuses on progress in the synthesis of chitosan and modified chitosan nanoparticles for efficient oral insulin delivery, with an emphasis on the biological efficacy of the nanoparticles. Obstacles to oral delivery and possible remedies are also brought into focus. Modifications to protect insulin from the harsh acidic environment of the gastro-intestinal (GI) tract are described. Chemical barriers such as the acidic gastric pH and the presence of proteolytic enzymes in the stomach and intestine limit the effective absorption of external insulin within the GI tract. Absorption of insulin is physically hindered by the absorption barrier consisting of a single layer of columnar epithelial cells joined at the apical surface by a tight junction complex. The presence of negative charges in the junction complex leads to segregation of the apical layer from the basolateral compartment of the epithelial cells, making the intestinal environment selective for particles based on size and charge. Nanoparticles are able to overcome these barriers and deliver insulin. While this technology still has some drawbacks, chitosan and modified chitosan nanoparticles are highly promising agents for oral insulin delivery. © 2012 Elsevier Ltd.
Citation: Progress in Polymer Science (2012), 37(11): 1457-1475
URI: https://doi.org/10.1016/j.progpolymsci.2012.04.004
http://repository.iitr.ac.in/handle/123456789/2304
Issue Date: 2012
Keywords: Chitosan
Effective bio-availability
Insulin
Nanoparticles
Oral delivery
ISSN: 796700
Author Scopus IDs: 55235955100
25643271200
7007036653
35475516300
Author Affiliations: Mukhopadhyay, P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India, Department of Physiology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India
Mishra, R., Department of Physiology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India
Rana, D., Industrial Membrane Research Institute, Department of Chemical and Biological Engineering, University of Ottawa, 161 Louis Pasteur St., Ottawa, ON K1N 6N5, Canada
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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