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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2301
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dc.contributor.authorMukhopadhyay P.-
dc.contributor.authorSarkar K.-
dc.contributor.authorChakraborty M.-
dc.contributor.authorBhattacharya S.-
dc.contributor.authorMishra R.-
dc.contributor.authorKundu, Patit Paban-
dc.date.accessioned2020-10-06T14:09:03Z-
dc.date.available2020-10-06T14:09:03Z-
dc.date.issued2013-
dc.identifier.citationMaterials Science and Engineering C (2013), 33(1): 376-382-
dc.identifier.issn9284931-
dc.identifier.other25428084-
dc.identifier.urihttps://doi.org/10.1016/j.msec.2012.09.001-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/2301-
dc.description.abstractWe have developed self-assembled chitosan/insulin nanoparticles for successful oral insulin delivery. The main purpose of our study is to prepare chitosan/insulin nanoparticles by self-assembly method, to characterize them and to evaluate their efficiency in vivo diabetic model. The size and morphology of the nanoparticles were analyzed by dynamic light scattering (DLS), atomic force microscopy (AFM) and scanning electron microscopy (SEM). The average particle size ranged from 200 to 550 nm, with almost spherical or sub spherical shape. An average insulin encapsulation within the nanoparticles was ~ 85%. In vitro release study showed that the nanoparticles were also efficient in retaining good amount of insulin in simulated gastric condition, while significant amount of insulin release was noticed in simulated intestinal condition. The oral administrations of chitosan/insulin nanoparticles were effective in lowering the blood glucose level of alloxan-induced diabetic mice. Thus, self-assembled chitosan/insulin nanoparticles show promising effects as potential insulin carrier system in animal models. © 2012 Elsevier B.V.-
dc.language.isoen_US-
dc.relation.ispartofMaterials Science and Engineering C-
dc.subjectChitosan-
dc.subjectInsulin-
dc.subjectNanoparticles-
dc.subjectOral delivery-
dc.subjectSelf-assembly-
dc.titleOral insulin delivery by self-assembled chitosan nanoparticles: In vitro and in vivo studies in diabetic animal model-
dc.typeArticle-
dc.scopusid55235955100-
dc.scopusid35771416500-
dc.scopusid35809824000-
dc.scopusid57072241500-
dc.scopusid25643271200-
dc.scopusid35475516300-
dc.affiliationMukhopadhyay, P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata-700009, India-
dc.affiliationSarkar, K., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata-700009, India-
dc.affiliationChakraborty, M., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata-700009, India-
dc.affiliationBhattacharya, S., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata-700009, India-
dc.affiliationMishra, R., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata-700009, India-
dc.affiliationKundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata-700009, India-
dc.description.correspondingauthorKundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata-700009, India; email: ppk923@yahoo.com-
Appears in Collections:Journal Publications [CH]

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