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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2291
Title: Formulation of pH-responsive carboxymethyl chitosan and alginate beads for the oral delivery of insulin
Authors: Mukhopadhyay P.
Sarkar K.
Soam S.
Kundu, Patit Paban
Published in: Journal of Applied Polymer Science
Abstract: pH-sensitive beads were prepared from the interpenetrating polymer networks (IPNs) of carboxymethyl chitosan (CMCTS) and alginate to study their application in oral insulin administration. CMCTS was synthesized from chitosan and was characterized by Fourier transform infrared spectroscopy and wide-angle X-ray diffraction. Calcium chloride, a relatively less toxic material, was used to crosslink both the alginate and CMCTS to prepare the IPN beads. The IPN beads were used to encapsulate insulin at different weight ratios. The swelling behavior and insulin release profile in response to simulated gastric and intestinal media of the beads were investigated. The beads observed under scanning electron microscopy were almost spherical, with an average diameter of 780 ?m. The bead with about a 54% insulin loading efficiency was observed to contain about 98% encapsulated insulin. The maxima of about 20% insulin retention at acidic pH (1.2) and about 94% insulin release at intestinal pH (7.4) justified the good pH-responsive nature of these IPN beads. Moreover, the insulin released from the IPN beads was stable and biologically active. Copyright © 2012 Wiley Periodicals, Inc.
Citation: Journal of Applied Polymer Science (2013), 129(2): 835-845
URI: https://doi.org/10.1002/app.38814
http://repository.iitr.ac.in/handle/123456789/2291
Issue Date: 2013
Keywords: biomedical applications
crosslinking
drug-delivery systems
gels
ISSN: 218995
Author Scopus IDs: 55235955100
35771416500
25926018100
35475516300
Author Affiliations: Mukhopadhyay, P., Department of Polymer Science and Technology, University of Calcutta, 92, A. P. C. Road, Kolkata 700009, India
Sarkar, K., Department of Polymer Science and Technology, University of Calcutta, 92, A. P. C. Road, Kolkata 700009, India
Soam, S., Department of Polymer Science and Technology, University of Calcutta, 92, A. P. C. Road, Kolkata 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92, A. P. C. Road, Kolkata 700009, India
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92, A. P. C. Road, Kolkata 700009, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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