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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/22873
Title: Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk
Authors: Kumar, Arun
Ali M.
Kumar R.
Kumar M.
Sagar P.
Pandey R.K.
Akhouri V.
Kumar V.
Anand G.
Niraj P.K.
Rani R.
Kumar S.
Kumar D.
Bishwapriya A.
Ghosh A.K.
Published in: Scientific Reports
Abstract: Reportedly, 300 million people worldwide are affected by the consumption of arsenic contaminated groundwater. India prominently figures amongst them and the state of Bihar has shown an upsurge in cases affected by arsenic poisoning. Escalated arsenic content in blood, leaves 1 in every 100 human being highly vulnerable to being affected by the disease. Uncontrolled intake may lead to skin, kidney, liver, bladder, or lung related cancer but even indirect forms of cancer are showing up on a regular basis with abnormal arsenic levels as the probable cause. But despite the apparent relation, the etiology has not been understood clearly. Blood samples of 2000 confirmed cancer patients were collected from pathology department of our institute. For cross-sectional design, 200 blood samples of subjects free from cancer from arsenic free pockets of Patna urban agglomeration, were collected. Blood arsenic levels in carcinoma patients as compared to sarcomas, lymphomas and leukemia were found to be higher. The geospatial map correlates the blood arsenic with cancer types and the demographic area of Gangetic plains. Most of the cancer patients with high blood arsenic concentration were from the districts near the river Ganges. The raised blood arsenic concentration in the 2000 cancer patients strongly correlates the relationship of arsenic with cancer especially the carcinoma type which is more vulnerable. The average arsenic concentration in blood of the cancer patients in the Gangetic plains denotes the significant role of arsenic which is present in endemic proportions. Thus, the study significantly correlates and advocates a strong relation of the deleterious element with the disease. It also underlines the need to address the problem by deciphering the root cause of the elevated cancer incidences in the Gangetic basin of Bihar and its association with arsenic poisoning. © 2021, The Author(s).
Citation: Scientific Reports, 11(1)
URI: https://doi.org/10.1038/s41598-021-81579-9
http://repository.iitr.ac.in/handle/123456789/22873
Issue Date: 2021
Publisher: Nature Research
Keywords: arsenic
biological marker
adult
adverse event
aged
arsenic poisoning
blood
case control study
complication
environmental exposure
female
human
male
medical geography
middle aged
neoplasm
risk assessment
risk factor
spatiotemporal analysis
young adult
Adult
Aged
Arsenic
Arsenic Poisoning
Biomarkers
Case-Control Studies
Environmental Exposure
Female
Geography, Medical
Humans
Male
Middle Aged
Neoplasms
Risk Assessment
Risk Factors
Spatio-Temporal Analysis
Young Adult
ISSN: 20452322
Author Scopus IDs: 57202315437
57202879279
57226630758
57214630365
57196570211
57221692675
57218581477
57220974655
57190617440
57190618481
57221693091
57215054580
57211099780
56394636500
7403964617
Author Affiliations: Kumar, A., Mahavir Cancer Sansthan and Research Centre, Patna, Bihar 801505, India
Ali, M., Mahavir Cancer Sansthan and Research Centre, Patna, Bihar 801505, India
Kumar, R., Department of Animal Sciences, Central University of Himachal Pradesh, Kangra, Himachal Pradesh, India
Kumar, M., Mahavir Cancer Sansthan and Research Centre, Patna, Bihar 801505, India
Sagar, P., Mahavir Cancer Sansthan and Research Centre, Patna, Bihar 801505, India
Pandey, R.K., Mahavir Cancer Sansthan and Research Centre, Patna, Bihar 801505, India
Akhouri, V., Mahavir Cancer Sansthan and Research Centre, Patna, Bihar 801505, India
Kumar, V., Mahavir Cancer Sansthan and Research Centre, Patna, Bihar 801505, India
Anand, G., Mahavir Cancer Sansthan and Research Centre, Patna, Bihar 801505, India
Niraj, P.K., Mahavir Cancer Sansthan and Research Centre, Patna, Bihar 801505, India
Rani, R., Mahavir Cancer Sansthan and Research Centre, Patna, Bihar 801505, India
Kumar, S., Department of Applied Geoscience and Engineering, Delft University of Technology, Delft, Netherlands
Kumar, D., Amity Institute of Molecular Medicine and Stem Cell Research, Amity University Uttar Pradesh, Noida, India
Bishwapriya, A., Geological Survey of India, Patna, Bihar, India
Ghosh, A.K., Mahavir Cancer Sansthan and Research Centre, Patna, Bihar 801505, India
Corresponding Author: Kumar, A.; Mahavir Cancer Sansthan and Research CentreIndia; email: drarunk31@gmail.com
Appears in Collections:Journal Publications [HRE]

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