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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2284
Title: Efficient oral insulin delivery by dendronized chitosan: In vitro and in vivo studies
Authors: Mukhopadhyay P.
Sarkar K.
Bhattacharya S.
Mishra R.
Kundu, Patit Paban
Published in: RSC Advances
Abstract: The development of efficient and bio-safe polymeric carriers for oral insulin delivery is a major thrust in biomedical research. In this paper, dendronized chitosan (DCTS) is prepared using a Michael-type addition reaction by grafting polyamidoamine (PAMAM) onto chitosan to improve its water solubility, pH sensitivity, and insulin encapsulation efficiency for enhanced bioavailability of the oral insulin. The self-assembled dendronized chitosan nanoparticles are prepared using a mild coacervation method, in which almost sub-spherically shaped nanoparticles of 85-150 nm size are produced, with an insulin encapsulation of approx. 95%. In vitro release study confirms a pH-sensitive and self-sustained release of insulin, where the oral administration of these nanoparticles exhibits a pronounced hypoglycemic effect in diabetic mice, producing a relative bioavailability of ?9.19%. As no systemic toxicity is observed with its peroral delivery, these DCTS nanoparticles can effectively serve as a promising device in the efficient administration of oral insulin. This journal is © the Partner Organisations 2014.
Citation: RSC Advances (2014), 4(83): 43890-43902
URI: https://doi.org/10.1039/c4ra07511k
http://repository.iitr.ac.in/handle/123456789/2284
Issue Date: 2014
Publisher: Royal Society of Chemistry
ISSN: 20462069
Author Scopus IDs: 55235955100
35771416500
57072241500
25643271200
35475516300
Author Affiliations: Mukhopadhyay, P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Sarkar, K., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Bhattacharya, S., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Mishra, R., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, India
Appears in Collections:Journal Publications [CH]

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