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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2268
Title: Synthesis of a novel pH-sensitive polyurethane-alginate blend with poly(ethylene terephthalate) waste for the oral delivery of protein
Authors: Bhattacharyya A.
Mukhopadhyay P.
Kundu, Patit Paban
Published in: Journal of Applied Polymer Science
Abstract: With the aim of using poly(ethylene terephthalate) (PET) waste for the synthesis of a value added product, we prepared polyurethane (PU) from bishydrohxyethylene terephthalate (BHET), a byproduct obtained from the glycolysis of PET. Biodegradable, water-swelling PU was synthesized by the reaction of BHET, hexamethylene diisocyanate, and poly(ethylene glycol) (PEG). Both BHET and PU were characterized by Fourier transform infrared spectroscopy, and the formation of PU was further confirmed by NMR analysis. The swelling behavior of PU in water was examined in terms of the various molecular weights of PEG. Semi-interpenetrating network beads of PU and sodium alginate were prepared with calcium chloride (CaCl2) as a crosslinker to attain a pH sensitivity for successful oral protein/drug delivery. Bovine serum albumin (BSA) was used as a model protein. The pH-responsive swelling behavior and protein (BSA) release kinetics in different pH media corresponding to the gastrointestinal tract (pH 1.2 and 7.4) were investigated. The degree of swelling in the case of the PU-alginate beads at pH 1.2 was found to be at a minimum, whereas the degree of swelling was significantly elevated (1080%) at pH 7.4. This substantiated the pH sensitivity of the polymeric beads with a minimum loss of encapsulated protein in the stomach and the almost complete release of encapsulated protein in the intestine. This revealed good opportunities for oral protein/drug delivery with a polymer derived from waste PET. Moreover, the fungal biodegradation study confirmed its compatibility with the ecological system. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40650. Copyright © 2014 Wiley Periodicals, Inc.
Citation: Journal of Applied Polymer Science (2014), 131(16): -
URI: https://doi.org/10.1002/app.40650
http://repository.iitr.ac.in/handle/123456789/2268
Issue Date: 2014
Publisher: John Wiley and Sons Inc.
Keywords: biodegradable
biomedical applications
drug-delivery systems
polyurethanes
ISSN: 218995
Author Scopus IDs: 56075861300
55235955100
35475516300
Author Affiliations: Bhattacharyya, A., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India
Mukhopadhyay, P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700009, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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