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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2265
Title: PH sensitive N-succinyl chitosan grafted polyacrylamide hydrogel for oral insulin delivery
Authors: Mukhopadhyay P.
Sarkar K.
Bhattacharya S.
Bhattacharyya A.
Mishra R.
Kundu, Patit Paban
Published in: Carbohydrate Polymers
Abstract: pH sensitive PAA/S-chitosan hydrogel was prepared using ammonium persulfate (APS) as an initiator and methylenebisacrylamide (MBA) as a crosslinker for oral insulin delivery. The synthesized copolymer was characterized by Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) study; morphology was observed under scanning electron microscope (SEM). The PAA/S-chitosan with ?38% of insulin loading efficiency (LE) and ?76% of insulin encapsulation efficiency (EE), showed excellent pH sensitivity, retaining ?26% of encapsulated insulin in acidic stomach pH 1.2 and releasing of ?98% of insulin in the intestine (pH 7.4), providing a prolonged attachment with the intestinal tissue. The oral administration of insulin loaded PAA/S-chitosan hydrogel was successful in lowering the blood glucose level of diabetic mice. The bioavailability of insulin was ?4.43%. Furthermore, no lethality or toxicity was documented after its peroral administration. Thus, PAA/S-chitosan hydrogel could serve as a promising oral insulin carrier in future. © 2014 Elsevier Ltd.
Citation: Carbohydrate Polymers (2014), 112(): 627-637
URI: https://doi.org/10.1016/j.carbpol.2014.06.045
http://repository.iitr.ac.in/handle/123456789/2265
Issue Date: 2014
Publisher: Elsevier Ltd
Keywords: Hydrogel
Oral insulin delivery
pH sensitivity
S-chitosan
ISSN: 1448617
Author Scopus IDs: 55235955100
35771416500
57072241500
56075861300
25643271200
35475516300
Author Affiliations: Mukhopadhyay, P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India
Sarkar, K., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India
Bhattacharya, S., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India
Bhattacharyya, A., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India
Mishra, R., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India
Funding Details: We are highly grateful to Department of Science and Technology, Government of West Bengal for their financial support for this work and the project entitled ‘ Synthesis of derivatives of chitosan and their IPNs for oral insulin delivery ’; Sanction No. 428 (Sanc.)/ST/P/S & T/2G-7/2011 . Appendix A
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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