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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2263
Title: Characterization and evaluation of curcumin loaded guar gum/polyhydroxyalkanoates blend films for wound healing applications
Authors: Pramanik N.
Mitra T.
Khamrai M.
Bhattacharyya A.
Mukhopadhyay P.
Gnanamani A.
Basu R.K.
Kundu, Patit Paban
Published in: RSC Advances
Abstract: The present paper explores the 'in situ' fabrication of guar gum/polyhydroxyalkanoates-curcumin blend (GPCC) films in view of their increasing applications as wound dressings and antibacterial materials. Curcumin is incorporated to assess its bactericidal activity and to enhance the production and accumulation of the extracellular matrix in the healing process. In order to characterize the nature of the polymer network in the blend, FTIR/ATR spectra analysis and TGA are performed. The results reveal that the rigidity of the guar gum/PHBV blend improves with the increase of PHBV content due to the formation of non-covalent interactions, especially H-bonds, between these molecules. Electron microscopy analyses reveal the homogenecity of the blends and surface roughness of the blended films, favoring cell attachment and cell proliferation compared with the film without curcumin. The anti-microbial study demonstrate that the bactericidal activity is more effective against Gram-positive strains than Gram-negative strains. Results of the in vivo wound healing study in an animal model demonstrates that the developed curcumin loaded guar gum/PHBV blend film shows markedly enhanced wound healing compared to the control one. © 2015 The Royal Society of Chemistry.
Citation: RSC Advances (2015), 5(78): 63489-63501
URI: https://doi.org/10.1039/c5ra10114j
http://repository.iitr.ac.in/handle/123456789/2263
Issue Date: 2015
Publisher: Royal Society of Chemistry
ISSN: 20462069
Author Scopus IDs: 56324545100
39863189900
56641668300
56075861300
55235955100
6602667464
7101688201
35475516300
Author Affiliations: Pramanik, N., Advanced Polymer Laboratory, Department of Polymer Science and Technology, University of Calcutta, Kolkata, 700009, India
Mitra, T., Advanced Polymer Laboratory, Department of Polymer Science and Technology, University of Calcutta, Kolkata, 700009, India
Khamrai, M., Advanced Polymer Laboratory, Department of Polymer Science and Technology, University of Calcutta, Kolkata, 700009, India
Bhattacharyya, A., Advanced Polymer Laboratory, Department of Polymer Science and Technology, University of Calcutta, Kolkata, 700009, India
Mukhopadhyay, P., Advanced Polymer Laboratory, Department of Polymer Science and Technology, University of Calcutta, Kolkata, 700009, India
Gnanamani, A., Central Leather Research Institute, Department of Biological Science (CLRI), Chennai, India
Basu, R.K., Department of Chemical Engineering, University of Calcutta, Kolkata, 700009, India
Kundu, P.P., Advanced Polymer Laboratory, Department of Polymer Science and Technology, University of Calcutta, Kolkata, 700009, India
Corresponding Author: Kundu, P.P.; Advanced Polymer Laboratory, Department of Polymer Science and Technology, University of CalcuttaIndia
Appears in Collections:Journal Publications [CH]

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