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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2262
Title: Development of porous and antimicrobial CTS-PEG-HAP-ZnO nano-composites for bone tissue engineering
Authors: Bhowmick A.
Pramanik N.
Manna P.J.
Mitra T.
Raja Selvaraj T.K.
Gnanamani A.
Das M.
Kundu, Patit Paban
Published in: RSC Advances
Abstract: Herein, we have developed hybrid nanocomposites of chitosan, poly(ethylene glycol) and nano-hydroxyapatite-zinc oxide with interconnected macroporous structures for bone tissue engineering. These nanocomposites were characterized using different spectroscopic and analytical techniques. The percentage of porosity and the tensile strength of these materials were found to be similar to that of human cancellous bone. Moreover, these hybrid materials exhibited bio-degradability, a neutral pH (7.4) and erythrocyte compatibility. The addition of nano-hydroxyapatite-zinc oxide into the nanocomposites increased the antimicrobial activity and protein adsorption ability. The water uptake ability was found to increase with increasing the proportion of poly(ethylene glycol). Finally, osteoblast-like MG-63 cells were grown, attached and proliferated with these nanocomposites without them having any negative effect and the nanocomposites showed good cytocompatibility. © 2015 The Royal Society of Chemistry.
Citation: RSC Advances (2015), 5(120): 99385-99393
URI: https://doi.org/10.1039/c5ra16755h
http://repository.iitr.ac.in/handle/123456789/2262
Issue Date: 2015
Publisher: Royal Society of Chemistry
ISSN: 20462069
Author Scopus IDs: 53986105300
56324545100
56526470800
39863189900
56980002700
6602667464
35585815900
35475516300
Author Affiliations: Bhowmick, A., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Pramanik, N., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Manna, P.J., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Mitra, T., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Raja Selvaraj, T.K., Microbiology Division, CSIR-Central Leather Research Institute, Adyar, Chennai, Tamil Nadu, 600020, India
Gnanamani, A., Microbiology Division, CSIR-Central Leather Research Institute, Adyar, Chennai, Tamil Nadu, 600020, India
Das, M., Department of Chemical Engineering, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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