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dc.contributor.authorMukhopadhyay P.-
dc.contributor.authorChakraborty S.-
dc.contributor.authorBhattacharya S.-
dc.contributor.authorMishra R.-
dc.contributor.authorKundu, Patit Paban-
dc.date.accessioned2020-10-06T14:08:54Z-
dc.date.available2020-10-06T14:08:54Z-
dc.date.issued2015-
dc.identifier.citationInternational Journal of Biological Macromolecules (2015), 72(): 640-648-
dc.identifier.issn1418130-
dc.identifier.other25239194-
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2014.08.040-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/2260-
dc.description.abstractChitosan-alginate (CS/ALG) nanoparticles were prepared by formation of an ionotropic pre-gelation of an alginate (ALG) core entrapping insulin, followed by chitosan (CS) polyelectrolyte complexation, for successful oral insulin administration. Mild preparation process without harsh chemicals is aimed at improving insulin bio-efficiency in in vivo model. The nanoparticles showed an average particle size of 100-200. nm in dynamic light scattering (DLS), with almost spherical or sub-spherical shape and ~85% of insulin encapsulation. Again, retention of almost entire amount of encapsulated insulin in simulated gastric buffer followed by its sustained release in simulated intestinal condition proved its pH sensitivity in in vitro release studies. Significant hypoglycemic effects with improved insulin-relative bioavailability (~8.11%) in in vivo model revealed the efficacy of these core-shell nanoparticles of CS/ALG as an oral insulin carrier. No systemic toxicity was found after its peroral treatment, suggesting these core-shell nanoparticles as a promising device for potential oral insulin delivery. © 2014 Elsevier B.V.-
dc.language.isoen_US-
dc.publisherElsevier-
dc.relation.ispartofInternational Journal of Biological Macromolecules-
dc.subjectBioavailability-
dc.subjectChitosan/alginate pH-sensitive nanoparticles-
dc.subjectOral insulin delivery-
dc.titlePH-sensitive chitosan/alginate core-shell nanoparticles for efficient and safe oral insulin delivery-
dc.typeArticle-
dc.scopusid55235955100-
dc.scopusid35097174600-
dc.scopusid57072241500-
dc.scopusid25643271200-
dc.scopusid35475516300-
dc.affiliationMukhopadhyay, P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India-
dc.affiliationChakraborty, S., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India-
dc.affiliationBhattacharya, S., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India-
dc.affiliationMishra, R., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India-
dc.affiliationKundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India-
dc.description.fundingWe are highly grateful to the Department of Science and Technology, Government of West Bengal, for their financial support for this work and the project entitled ‘Synthesis of derivatives of chitosan and their IPNs for oral insulin delivery’ (Sanction No. 428 (sanc.)/ST/P/S&T/2G-7/2011).-
dc.description.correspondingauthorKundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, India-
Appears in Collections:Journal Publications [CH]

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