Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2260
Title: PH-sensitive chitosan/alginate core-shell nanoparticles for efficient and safe oral insulin delivery
Authors: Mukhopadhyay P.
Chakraborty S.
Bhattacharya S.
Mishra R.
Kundu, Patit Paban
Published in: International Journal of Biological Macromolecules
Abstract: Chitosan-alginate (CS/ALG) nanoparticles were prepared by formation of an ionotropic pre-gelation of an alginate (ALG) core entrapping insulin, followed by chitosan (CS) polyelectrolyte complexation, for successful oral insulin administration. Mild preparation process without harsh chemicals is aimed at improving insulin bio-efficiency in in vivo model. The nanoparticles showed an average particle size of 100-200. nm in dynamic light scattering (DLS), with almost spherical or sub-spherical shape and ~85% of insulin encapsulation. Again, retention of almost entire amount of encapsulated insulin in simulated gastric buffer followed by its sustained release in simulated intestinal condition proved its pH sensitivity in in vitro release studies. Significant hypoglycemic effects with improved insulin-relative bioavailability (~8.11%) in in vivo model revealed the efficacy of these core-shell nanoparticles of CS/ALG as an oral insulin carrier. No systemic toxicity was found after its peroral treatment, suggesting these core-shell nanoparticles as a promising device for potential oral insulin delivery. © 2014 Elsevier B.V.
Citation: International Journal of Biological Macromolecules (2015), 72(): 640-648
URI: https://doi.org/10.1016/j.ijbiomac.2014.08.040
http://repository.iitr.ac.in/handle/123456789/2260
Issue Date: 2015
Publisher: Elsevier
Keywords: Bioavailability
Chitosan/alginate pH-sensitive nanoparticles
Oral insulin delivery
ISSN: 1418130
Author Scopus IDs: 55235955100
35097174600
57072241500
25643271200
35475516300
Author Affiliations: Mukhopadhyay, P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Chakraborty, S., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Bhattacharya, S., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Mishra, R., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Funding Details: We are highly grateful to the Department of Science and Technology, Government of West Bengal, for their financial support for this work and the project entitled ‘Synthesis of derivatives of chitosan and their IPNs for oral insulin delivery’ (Sanction No. 428 (sanc.)/ST/P/S&T/2G-7/2011).
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, India
Appears in Collections:Journal Publications [CH]

Files in This Item:
There are no files associated with this item.
Show full item record


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.