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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2243
Title: Assessment of in vivo chronic toxicity of chitosan and its derivates used as oral insulin carriers
Authors: Mukhopadhyay P.
Bhattacharya S.
Nandy A.
Bhattacharyya A.
Mishra R.
Kundu, Patit Paban
Published in: Toxicology Research
Abstract: Considering public health protection, the carrier system for oral insulin must be safe. Hence, in the present study, the chronic oral toxicity of chitosan derivates was investigated in a mouse model. Oral administration of polymers did not cause any significant change in the behavioural pattern, body weight, and clinical symptoms of the treated mice. There were also no significant alterations in the biochemical parameters of blood serum and urine. Further, histopathological examination revealed an almost normal architecture, suggesting no significant adverse effects on the liver, kidney and intestine of the treated animals. An in vitro haemolysis assay proved that chitosan and its derivatives were blood compatible. Finally, intestinal luminal bacteria were able to biodegrade the polymers completely. Overall, the results suggested that the oral administration of the derivatives of chitosan in mice did not produce any significant toxicity in chronic treatment. Hence, these polymers could be utilized as safe devices for oral delivery of insulin and also other drugs. This journal is © 2015 The Royal Society of Chemistry.
Citation: Toxicology Research (2015), 4(2): 281-290
URI: https://doi.org/10.1039/c4tx00102h
http://repository.iitr.ac.in/handle/123456789/2243
Issue Date: 2015
Publisher: Royal Society of Chemistry
ISSN: 2045452X
Author Scopus IDs: 55235955100
57072241500
55813019000
56075861300
25643271200
35475516300
Author Affiliations: Mukhopadhyay, P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Bhattacharya, S., Department of Physiology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Nandy, A., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Bhattacharyya, A., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Mishra, R., Department of Physiology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, India
Appears in Collections:Journal Publications [CH]

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