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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2240
Title: Potential use of curcumin loaded carboxymethylated guar gum grafted gelatin film for biomedical applications
Authors: Manna P.J.
Mitra T.
Pramanik N.
Kavitha V.
Gnanamani A.
Kundu, Patit Paban
Published in: International Journal of Biological Macromolecules
Abstract: Present study describes the synthesis of carboxylmethyl guar gum (CMGG) from the native guar gum (GG). Further, the prepared CMGG is grafted with gelatin to form CMGG-g-gelatin and then mixed with curcumin to prepare a biomaterial. The resultant biomaterial is subjected to the analysis of 1H NMR, ATR-FTIR, TGA, SEM and XRD ensure the carboxymethylation and grafting. The results reveal that 45% of the amine groups of gelatin have been reacted with the COOH group of CMGG and 90-95% of curcumin is released from CMGG-g-gelatin after 96h of incubation in the phosphate buffer at physiological pH. In vitro cell line studies reveal the biocompatibility of the biomaterial and the antimicrobial studies display the growth inhibition against gram +ve and gram -ve organisms at a considerable level. Overall, the study indicates that the incorporation of curcumin into CMGG-g-gelatin can improve the functional property of guar gum as well as gelatin. © 2015.
Citation: International Journal of Biological Macromolecules (2015), 75(): 437-446
URI: https://doi.org/10.1016/j.ijbiomac.2015.01.047
http://repository.iitr.ac.in/handle/123456789/2240
Issue Date: 2015
Publisher: Elsevier
Keywords: Curcumin
Gelatin
Guar gum
ISSN: 1418130
Author Scopus IDs: 56526470800
39863189900
56324545100
6603593547
6602667464
35475516300
Author Affiliations: Manna, P.J., Department of Polymer Science and Technology, University of Calcutta, University College of Science and Technology, 92, A.P.C road, Kolkata, West Bengal, 700009, India
Mitra, T., Department of Polymer Science and Technology, University of Calcutta, University College of Science and Technology, 92, A.P.C road, Kolkata, West Bengal, 700009, India
Pramanik, N., Department of Polymer Science and Technology, University of Calcutta, University College of Science and Technology, 92, A.P.C road, Kolkata, West Bengal, 700009, India
Kavitha, V., Microbiology Division, CSIR-Central Leather Research Institute, Adyar, Chennai, Tamil Nadu, 600020, India
Gnanamani, A., Microbiology Division, CSIR-Central Leather Research Institute, Adyar, Chennai, Tamil Nadu, 600020, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, University College of Science and Technology, 92, A.P.C road, Kolkata, West Bengal, 700009, India
Funding Details: One of the authors Dr. Tapas Mitra acknowledges UGC, New Delhi for financial assistance provided in the form of Dr. D. S. Kothari Post Doctoral Fellowship.
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, University College of Science and Technology, 92, A.P.C road, India
Appears in Collections:Journal Publications [CH]

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