http://repository.iitr.ac.in/handle/123456789/2217| Title: | Modified chitosan encapsulated core-shell Ag Nps for superior antimicrobial and anticancer activity |
| Authors: | Banerjee S.L. Khamrai M. Sarkar K. Singha N.K. Kundu, Patit Paban |
| Published in: | International Journal of Biological Macromolecules |
| Abstract: | This investigation reports a one pot synthesis of silver nanoparticles (Ag Nps) using aqueous solution of chitosan-graft-poly(acrylamide) (Cts-g-PAAm) as a reducing agent and polyethylene glycol (PEG) as a stabilizing agent. The as synthesized Ag Nps was characterized by ultra violet-visible (UV-vis), Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analysis. Field emission scanning electron microscopy (FESEM), dynamic light scattering (DLS) and transmission electron microscopy (TEM) showed that Ag Nps, which were stable upto more than 60 days, were spherical in shape and the particle size was in the range of 5-50nm. Atomic force microscopy (AFM) image also supported the above obtained result. The prepared Ag Nps exhibited strong antimicrobial activity against different gram positive bacteria (Alkaliphilus, Bascillus substillis, Lysinibascillus) and gram negative bacteria (Enterobacter aerogenus, Vivbrio vulnificus and Escherichia coli) and haemolytic assay revealed its blood compatible nature. The synthesized Ag Nps showed significant cytotoxicity over human cervical HeLa cancer cells and it was found that the inhibitory concentration for 50% cell death (IC50) was 8?g/ml. © 2015 Elsevier B.V. |
| Citation: | International Journal of Biological Macromolecules (2016), 85(): 157-167 |
| URI: | https://doi.org/10.1016/j.ijbiomac.2015.12.068 http://repository.iitr.ac.in/handle/123456789/2217 |
| Issue Date: | 2016 |
| Publisher: | Elsevier B.V. |
| Keywords: | Antimicrobial activity Chitosan-g-poly(acrylamide) Cytotoxicity Polyethylene glycol Silver nanoparticles |
| ISSN: | 1418130 |
| Author Scopus IDs: | 56424674800 56641668300 35771416500 6701656205 35475516300 |
| Author Affiliations: | Banerjee, S.L., Department of Polymer Science and Technology, University of Calcutta, University College of Science and Technology, 92, A.P.C road, Kolkata, West Bengal, 700009, India, Rubber Technology Centre, Indian Institute of Technology, Kharagpur, 721302, India Khamrai, M., Department of Polymer Science and Technology, University of Calcutta, University College of Science and Technology, 92, A.P.C road, Kolkata, West Bengal, 700009, India Sarkar, K., Department of Polymer Science and Technology, University of Calcutta, University College of Science and Technology, 92, A.P.C road, Kolkata, West Bengal, 700009, India Singha, N.K., Rubber Technology Centre, Indian Institute of Technology, Kharagpur, 721302, India Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, University College of Science and Technology, 92, A.P.C road, Kolkata, West Bengal, 700009, India |
| Corresponding Author: | Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, University College of Science and Technology, 92, A.P.C road, India; email: ppk923@yahoo.com |
| Appears in Collections: | Journal Publications [CH] |
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