http://repository.iitr.ac.in/handle/123456789/2215
Title: | Development of biomimetic nanocomposites as bone extracellular matrix for human osteoblastic cells |
Authors: | Bhowmick A. Mitra T. Gnanamani A. Das M. Kundu, Patit Paban |
Published in: | Carbohydrate Polymers |
Abstract: | Here, we have developed biomimetic nanocomposites containing chitosan, poly(vinyl alcohol) and nano-hydroxyapatite-zinc oxide as bone extracellular matrix for human osteoblastic cells and characterized by Fourier transform infrared spectroscopy, powder X-ray diffraction. Scanning electron microscopy images revealed interconnected macroporous structures. Moreover, in this study, the problem related to fabricating a porous composite with good mechanical strength has been resolved by incorporating 5 wt% of nano-hydroxyapatite-zinc oxide into chitosan-poly(vinyl alcohol) matrix; the present composite showed high tensile strength (20.25 MPa) while maintaining appreciable porosity (65.25%). These values are similar to human cancellous bone. These nanocomposites also showed superior water uptake, antimicrobial and biodegradable properties than the previously reported results. Compatibility with human blood and pH was observed, indicating nontoxicity of these materials to the human body. Moreover, proliferation of osteoblastic MG-63 cells onto the nanocomposites was also observed without having any negative effect. © 2016 Elsevier Ltd. All rights reserved. |
Citation: | Carbohydrate Polymers (2016), 141(): 82-91 |
URI: | https://doi.org/10.1016/j.carbpol.2015.12.074 http://repository.iitr.ac.in/handle/123456789/2215 |
Issue Date: | 2016 |
Publisher: | Elsevier Ltd |
Keywords: | Chitosan Hydroxyapatite Nanocomposites Polyvinyl alcohol Zinc-oxide |
ISSN: | 1448617 |
Author Scopus IDs: | 53986105300 39863189900 6602667464 35585815900 35475516300 |
Author Affiliations: | Bhowmick, A., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India Mitra, T., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India Gnanamani, A., Microbiology Division, CSIR, Central Leather Research Institute, Adyar, Chennai, Tamil Nadu 600020, India Das, M., Department of Chemical Engineering, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India |
Corresponding Author: | Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, India; email: ppk923@yahoo.com |
Appears in Collections: | Journal Publications [CH] |
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