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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2215
Title: Development of biomimetic nanocomposites as bone extracellular matrix for human osteoblastic cells
Authors: Bhowmick A.
Mitra T.
Gnanamani A.
Das M.
Kundu, Patit Paban
Published in: Carbohydrate Polymers
Abstract: Here, we have developed biomimetic nanocomposites containing chitosan, poly(vinyl alcohol) and nano-hydroxyapatite-zinc oxide as bone extracellular matrix for human osteoblastic cells and characterized by Fourier transform infrared spectroscopy, powder X-ray diffraction. Scanning electron microscopy images revealed interconnected macroporous structures. Moreover, in this study, the problem related to fabricating a porous composite with good mechanical strength has been resolved by incorporating 5 wt% of nano-hydroxyapatite-zinc oxide into chitosan-poly(vinyl alcohol) matrix; the present composite showed high tensile strength (20.25 MPa) while maintaining appreciable porosity (65.25%). These values are similar to human cancellous bone. These nanocomposites also showed superior water uptake, antimicrobial and biodegradable properties than the previously reported results. Compatibility with human blood and pH was observed, indicating nontoxicity of these materials to the human body. Moreover, proliferation of osteoblastic MG-63 cells onto the nanocomposites was also observed without having any negative effect. © 2016 Elsevier Ltd. All rights reserved.
Citation: Carbohydrate Polymers (2016), 141(): 82-91
URI: https://doi.org/10.1016/j.carbpol.2015.12.074
http://repository.iitr.ac.in/handle/123456789/2215
Issue Date: 2016
Publisher: Elsevier Ltd
Keywords: Chitosan
Hydroxyapatite
Nanocomposites
Polyvinyl alcohol
Zinc-oxide
ISSN: 1448617
Author Scopus IDs: 53986105300
39863189900
6602667464
35585815900
35475516300
Author Affiliations: Bhowmick, A., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Mitra, T., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Gnanamani, A., Microbiology Division, CSIR, Central Leather Research Institute, Adyar, Chennai, Tamil Nadu 600020, India
Das, M., Department of Chemical Engineering, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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