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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2211
Title: Multifunctional zirconium oxide doped chitosan based hybrid nanocomposites as bone tissue engineering materials
Authors: Bhowmick A.
Jana P.
Pramanik N.
Mitra T.
Banerjee S.L.
Gnanamani A.
Das M.
Kundu P.P.
Published in: Carbohydrate Polymers
Abstract: This paper reports the development of multifunctional zirconium oxide (ZrO2) doped nancomposites having chitosan (CTS), organically modified montmorillonite (OMMT) and nano-hydroxyapatite (HAP). Formation of these nanocomposites was confirmed by various characterization techniques such as Fourier transform infrared spectroscopy and powder X-ray diffraction. Scanning electron microscopy images revealed uniform distribution of OMMT and nano-HAP-ZrO2 into CTS matrix. Powder XRD study and TEM study revealed that OMMT has partially exfoliated into the polymer matrix. Enhanced mechanical properties in comparison to the reported literature were obtained after the addition of ZrO2 nanoparticle into the nanocomposites. In rheological measurements, CMZH I–III exhibited greater storage modulus (G?) than loss modulus (G?). TGA results showed that these nanocomposites are thermally more stable compare to pure CTS film. Strong antibacterial zone of inhibition and the lowest minimum inhibition concentration (MIC) value of these nanocomposites against bacterial strains proved that these materials have the ability to prevent bacterial infection in orthopedic implants. Compatibility of these nanocomposites with pH and blood of human body was established. It was observed from the swelling study that the swelling percentage was increased with decreasing the hydrophobic OMMT content. Human osteoblastic MG-63 cell proliferations were observed on the nanocomposites and cytocompatibility of these nanocomposites was also established. Moreover, addition of 5 wt% OMMT and 5 wt% nano-HAP-ZrO2 into 90 wt% CTS matrix provides maximum tensile strength, storage modulus, aqueous swelling and cytocompatibility along with strong antibacterial effect, pH and erythrocyte compatibility. © 2016 Elsevier Ltd
Citation: Carbohydrate Polymers (2016), 151(): 879-888
URI: https://doi.org/10.1016/j.carbpol.2016.06.034
http://repository.iitr.ac.in/handle/123456789/2211
Issue Date: 2016
Publisher: Elsevier Ltd
Keywords: Chitosan
Hydroxyapatite
Montmorillonite
Zirconium-oxide
ISSN: 1448617
Author Scopus IDs: 53986105300
57102951300
56324545100
39863189900
56424674800
6602667464
35585815900
35475516300
Author Affiliations: Bhowmick, A., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Jana, P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Pramanik, N., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Mitra, T., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Banerjee, S.L., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Gnanamani, A., Microbiology Division, CSIR-Central Leather Research Institute, Adyar, Chennai, Tamil Nadu 600020, India
Das, M., Department of Chemical Engineering, University of Calcutta, 92?A.P.C. Road, Kolkata, 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India, Department of Chemical Engineering, Indian Institute of Technology, Roorkee, 247667, India
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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