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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2209
Title: Aromatic ?-Conjugated Curcumin on Surface Modified Polyaniline/Polyhydroxyalkanoate Based 3D Porous Scaffolds for Tissue Engineering Applications
Authors: Pramanik N.
Dutta K.
Basu R.K.
Kundu, Patit Paban
Published in: ACS Biomaterials Science and Engineering
Abstract: Curcumin-entrapped polyaniline (PAni)-conjugated poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) electroconductive porous scaffolds were fabricated for application in tissue engineering. The physical and chemical characterizations of the as-prepared biomaterials were performed by UV-vis and ATR/FT-IR spectrophotometric, thermogravimetric, fluorescence microscopic, and X-ray diffractometric analyses. It was observed that compared to the pure PHBV copolymer, which is an insulator, the electroconductivity of the PAni-modified PHBV copolymer increased up to the value of 5.78 × 10-5 S cm-1. An antimicrobial study revealed that the curcumin-loaded biomaterials exhibited better bactericidal effect against Gram-positive bacterial strains compared to Gram-negative strains. The composite also demonstrated significant compatibility toward blood and fibroblast cells and exhibited the maximum cell viability (90% to 80%). Cell migration and proliferation on the injured tissues were found to occur at a faster rate, resulting in faster repair, in the presence of anti-inflammatory and anticancer curcumin drug loaded composites compared to that of the pure PHBV copolymer. © 2016 American Chemical Society.
Citation: ACS Biomaterials Science and Engineering (2016), 2(12): 2365-2377
URI: https://doi.org/10.1021/acsbiomaterials.6b00595
http://repository.iitr.ac.in/handle/123456789/2209
Issue Date: 2016
Publisher: American Chemical Society
Keywords: curcumin
polyaniline
polyhydroxyalkanoates
porous 3D scaffold
tissue engineering
ISSN: 23739878
Author Scopus IDs: 56324545100
7005115695
7101688201
35475516300
Author Affiliations: Pramanik, N., Advanced Polymer Laboratory, Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700 009, India
Dutta, K., Advanced Polymer Laboratory, Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700 009, India
Basu, R.K., Department of Chemical Engineering, University of Calcutta, 92, A.P.C. Road, Kolkata, 700 009, India
Kundu, P.P., Advanced Polymer Laboratory, Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700 009, India, Department of Chemical Engineering, Indian Institute of Technology (IIT) Roorkee, Roorkee, Uttarakhand, 247667, India
Funding Details: N.P. acknowledges Technical Education Quality Improvement Programme (TEQIP), Govt. of India, for financial support (Award no. UGC-NFO-20145-2015). K.D. thanks the Council of Scientific and Industrial Research (CSIR), India, for a Senior Research Fellowship (Award no. 09/028 (0901)/2012-EMR-I).
Corresponding Author: Kundu, P.P.; Advanced Polymer Laboratory, Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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